Studies from James Cook University further understanding of abdominal aortic aneurysm genetics

New investigation results, 'Association of PPARgamma allelic variation, osteoprotegerin and abdominal aortic aneurysm,' are detailed in a study published in Clinical Endocrinology. "We have previously demonstrated high concentrations of the glycoprotein osteoprotegerin (OPG) in biopsies of abdominal aortic aneurysm (AAA), and demonstrated that ligation of the nuclear receptor peroxisome proliferator-activated receptor gamma (PPARgamma) downregulates OPG in vitro and within a mouse model. The aims of this study were to assess the associations between circulating concentrations of OPG, polymorphisms of the gene encoding PPARgamma (PPARG), AAA presence and growth," investigators in...

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