Heart Transplantation

Allosensitization a problem needing resolution, tolerance induction may work

Published in Cardiovascular Week, August 4th, 2003

In heart transplants, detection of allosensitization is not very sensitive, and there are many strategies being used to try to minimize sensitization; induction of tolerance may be the best future remedy.

"The detection of anti-human leukocyte antigen (HILA) donor-specific antibodies has been associated with a variety of clinical syndromes that determine short and long term outcomes of cardiac transplant recipients, including an increased incidence of early and more severe allograft rejection and cardiac allograft vasculopathy. Recent surveys indicate marked heterogeneity in clinical protocols for detection and management of sensitization in heart transplantation,"...

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Source: Cardiovascular Week (2003-08-04)

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