Cardiology
Reactive oxygen species are necessary mediators of coronary collateralization
Published in Cardiovascular Week, November 3rd, 2003
"Recent evidence suggests that reactive oxygen species (ROS) promote proliferation and migration of vascular smooth muscle (VSMC) and endothelial cells (EC). We tested the hypothesis that ROS serve as crucial messengers during coronary collateral development. Dogs were subjected to brief (2 min), repetitive coronary artery occlusions (1/h, 8/day, 21 day duration) in the absence (occlusion, n=8) or presence of N-acetylcysteine (NAC) (occlusion + NAC, n=8)," scientists in the United States reported.
"A sham group (n=8) was instrumented identically but received no occlusions....
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Source: Cardiovascular Week (2003-11-03)
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