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Clotting Predictors

Fibrin polymerization rate in antiphospholipid syndrome plus SLE may be a risk

Published in Cardiovascular Week, November 3rd, 2003

Patients with antiphospholipid syndrome plus lupus have an increased fibrin polymerization rate that may be a clotting risk.

"The main event in blood coagulation is the thrombin-catalyzed conversion of fibrinogen into fibrin. This singular transformation of a soluble protein into an insoluble polymeric network occurs with faultless precision. Abnormalities of fibrin polymerization can lead to hemorrhagic and thrombotic disorders," scientists in Mexico report.

"Increased fibrinogen plasma concentration (Fg) and fibrin polymerization rate (FPR) could be additional risk factors associated with atherothrombosis in antiphospholipid syndrome (APS) and in...

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