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Transfusion Medicine

Modified human hemoglobin enables targeted oxygen delivery

Published in Cardiovascular Week, November 3rd, 2003

A modified form of human hemoglobin shows promise for targeted oxygen delivery.

"To assess O2 delivery to tissue by a new surface-modified, polyethylene glycol-conjugated human hemoglobin [MP4; Po2 at 50% saturation of hemoglobin (P50 ); 5.4 mmHg]," scientists in California examined "micro-circulatory hemodynamics and O2 release in golden Syrian hamsters hemodiluted with MP4 or polymerized bovine hemoglobin (PolyBvHb; P50 54.2 mmHg)."

"Comparisons were made with the animals' hemodiluted blood with a non-O2 carrying plasma expander with similar solution properties (Dextran-70),"...

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