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Heart Transplantation

Allotrap peptide RDP58 inhibits aortic graft arteriosclerosis

Published in Cardiovascular Week, January 12th, 2004

Allotrap peptide RDP58 inhibits arteriosclerosis in aortic graft recipients.

According to published research from the United States, "There remains no treatment for chronic allograft rejection mainly manifested by progressive arteriosclerosis."

W. Li and coauthors at the University of Pittsburgh "investigated the effect of Allotrap peptide RDP58 therapy on arteriosclerosis in an aortic allotransplant model."

"RDP58 was administered intraperitoneally at 0.1, 0.5, or 2.5 mg/kg, every other day after transplantation," they explained. Test results showed that "RDP58 therapy markedly inhibited vascular intimal thickening, media...

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