Transplant Medicine

Late rejection may still be due to antibodies; diagnostics, cures are needed

Published in Cardiovascular Week, January 12th, 2004

Late rejections of organs, with slow deterioration, are still most likely to be antibody mediated; kidney damage can now be diagnosed, but lung and heart need reliable diagnostics.

According to a study from Canada, "some human organ transplants deteriorate slowly over a period of years, often developing characteristic syndromes: transplant glomerulopathy (TG) in kidneys, bronchiolitis obliterans in lungs, and coronary artery disease in hearts.

"In the past, we attributed late graft deterioration to chronic rejection, a distinct but mysterious immunologic process different from conventional rejection. However, it is likely that much of chronic...

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Source: Cardiovascular Week (2004-01-12)

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