Published in Cardiovascular Week, May 17th, 2004
According to recent research published in the journal Nature Structural and Molecular Biology, "Sodium channels initiate the electrical cascade responsible for cardiac rhythm, and certain life-threatening arrhythmias arise from Na+ channel dysfunction. We propose a novel mechanism for modulation of Na+ channel function whereby calcium ions bind directly to the human cardiac Na+ channel (hH1) via an E-hand motif in the C-terminal domain. A functional role for Ca2+ binding was identified electrophysiologically, by measuring Ca2+-induced modulation of...
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