Cardiology

Upregulation of NGF and GAP43 expression underlies cardiac nerve sprouting

Published in Cardiovascular Week, September 13th, 2004

Researchers in the United States have studied mechanisms of cardiac nerve sprouting after myocardial infarction in dogs.

"Cardiac nerve sprouting and sympathetic hyperinnervation after myocardial infarction (MI) both contribute to arrhythmogenesis and sudden death. However, the mechanisms responsible for nerve sprouting after MI are unclear," wrote S.M. Zhou and colleagues of the Cedars Sinai Medical Center.

The researchers described their study, "The expression of nerve growth factor (NGF), growth-associated protein 43 (GAP43), and other nerve markers were studied at the infarcted site, the noninfarcted left ventricle free wall (LVFW), and the left...

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Source: Cardiovascular Week (2004-09-13)

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