Cardiology
Review focuses on remodeling of myocardial gap junctions during hypertrophy
Published in Cardiovascular Week, February 14th, 2005
According to scientists in the Netherlands, "Cardiac hypertrophic remodeling, initiated by signaling cascades in response to increased workload, injury or intrinsic disease, is initially adaptive. However, prolonged hypertrophy as a consequence of pathological stress leads to maladaptive changes that increase the risk for fatal ventricular arrhythmias. One of these changes is the remodeling of myocardial gap junctions, which provide for electrical coupling of adjacent cardiomyocytes."
B.E. Teunissen and colleagues of the University of Utrecht continued,...
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Source: Cardiovascular Week (2005-02-14)
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