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Cardiovascular Week

Susan Hasty, Publisher

Table of Contents . . . March 21st, 2005

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Cardiovascular Week | Other Publications

Angiology - Inhibiting MMPs could ameliorate intimal thickening, prevent MI

COX-2 Inhibitors - Patients on COX-2 inhibitors should have an assessment of any CV risk factors

Coronary Artery Disease - Therapeutic goals were reached with atorvastatin+amlodipine

Protein Signals - Article reviews components of NADPH oxidases in leukocytes and vascular tissue

Stroke - MTHFR allele evaluation will help prevent/reduce morbidity caused by stroke

ACE Inhibitors - Cardioprotection of zofenopril is greater than non-sulphydryl ACE inhibitors

Addiction Medicine - Cocaine hydrolase gene delivery blunts the heart's response to cocaine

Age-Related Macular Degeneration - Company expands clinical testing of AdPEDF for wet AMD

Airway inflammation - Study examined role of JNK in structural changes of the airway

Alcohol Use - Sleep loss increases cardiovascular disease risks in alcoholics

Analgesia - New epidural technique may be applied in prolonged critical illness

Atherosclerosis - New findings in atherosclerosis described

Analgesia - Remifentanil provided effective, reliable analgesia during labor

Angina - Exercise tolerance is good screening test for chest pain patients

Angiology - Calcium-independent phospholipase studied, regulation clarified

Angiology - Media-like islands protect local sites, not entire artery from atheroma

Angiology - Researchers report details of new studies and findings in the area of angiology

Angiology - Treatments for isolated proximal LAD disease demonstrated good results

Atherosclerosis - Studies describe new findings in atherosclerosis research

Angioplasty - Stenting benefits diabetic patients undergoing angioplasty

Angiotensin - Adrenal glomerulosa cell physiology studied, effect of angiotensin shown

Angiotensinase - Angiotensinase activity studied, asymmetrical brain distribution revealed

Aortic Stenosis - Model identified parameters for improved hemodynamics during SNP infusion

Atherosclerosis - Data advance knowledge in atherosclerosis research

Atherosclerosis - Harvard inks agreement to launch major genotyping study in atherosclerosis

Cardiology - Reports advance knowledge in cardiology research

Atherosclerosis - Nobiletin may prevent atherosclerosis by inhibiting foam-cell formation

Atherosclerosis - Role of SOXF in vascular cells gives insight into response to oxidative stress

Atherosclerosis - Statin effects: location may be key

Atherosclerosis Progression - Lack of social support associated with faster progression of CAD in women

Cardiology - Researchers detail new studies and findings in the area of cardiology

Atherosclerosis Vaccine - Immunomodulation of atherosclerosis reviewed

Awards - Medical device company wins HCRIC Innovation of the Year awards

Business & Finance - Medical device company announces financial results

Business Update - ATP-focused company updates recent drug development and corporate activities

Business Update - Benephit Infusion System receives CE marking; company names Italian distributor

Business Update - Cardiac Science awards contract for lithium battery power packs for AEDs

Cardiology - Studies advance knowledge in cardiology research

Business Update - Companies ink agreements relating to engineered-tissue products

Business Update - Conference featured presentations by cardiovascular and cardiology companies

Business Update - Instrumentation company receives signed agreement from LLUMU

Business Update - Medical device company to close vascular bracytherapy business

Cardiac Cell Therapy - Review details clinical potential of stem cell sources for cardiac cell therapy

Cardiac Drug Therapy - AT1 -receptor antagonists are important CV protective drugs

Metabolic Syndrome - Researchers' findings advance metabolic syndrome research

Cardiac Drug Therapy - Interaction details could lead to drugs with fewer heart-related side effects

Cardiac Fibrosis - Effects of beta-adrenoceptor stimulation on cardiac fibrosis involve aldosterone

Cardiac Fibrosis - Increasing adenylyl cyclase expression could attenuate cardiac fibrosis

Cardiac Hypertrophy - Study examined mechanisms of hypertrophic growth in absence of NPRA signaling

Cardiac Hypertrophy - Yin Yang 1 decreases alpha-MyHC mRNA, protein expression in ventricular myocytes

Cardiac Research - Indices did not demonstrate differences for iNOS-/- mice subjected to MI

Cardiac Research - Nitroxyl is a more potent activator of skeletal ryanodine receptors than NO

Cardiac Surgery - Catheter closure of atrial defects in children is safe, and effective

Cardiac Treatment - Cardiac self-care plays a defining role in time to treatment

Cardiology - Aortic dilation involved the aortic root and the ascending aorta

Cardiology - Cardiac specialty must explore new innovations for the long-term future

Cardiology - Enzyme inhibitors attenuate ventricular dysfunction after pressure overload

Cardiology - Higher baseline pulse pressure associated with CAD progression in older women

Cardiology - Medical technology company promotes dual-chamber pacemakers

Cardiology - Ranolazine is a selective inhibitor of the late sodium current

Cardiology - Real-time 3D Doppler assay devised for pediatric mitral valve flow measurement

Cardiology - Recent findings in cardiology provide new insights

Cardiology - Study evaluated ECG findings of patients with LV hypertrabeculation

Cardiology - Study suggests surgery sooner than later for severe leaky heart valves

Cardiology - Technology co. announces ventricular assist device implanted in 300th patient

Cardiology - Tryptase is proangiogenic in the healing heart

Cardiothoracic Surgery - Surgeons must work with industry to drive change for cardiothoracic specialty

Cardiovascular Disease - Knowing risk factors, influences could prevent atherosclerosis in renal patients

Cardiovascular Disease - Lower plasma BNP levels may reduce burden on CV system in hemodialysis patients

Cardiovascular Disease - Mechanism may contribute to clinical link between myeloperoxidase and CV disease

Cardiovascular Disease - Pedometer company offers ten tips to keep hearts healthy

Cardiovascular Research - L-type Ca2+ channels are regulated by beta-adrenergic stimulation

Cardiovascular Research - Trials evaluated the effect of antichlamydial antibiotics on secondary CV events

Cardiovascular Surgery - Safety and efficacy of minimally invasive mitral valve surgery reviewed

Cerebrovascular Disease - B-type natriuretic peptide, C-reactive protein are independent predictors of CHF

Collaborations - Company signs research agreement with Detroit hospital to target ER care

Congenital Heart Disease - Authors describe approach to define heart failure in congenital heart disease.

Congenital Heart Disease - ENU-induced mutations may yield insights into genetic basis of CHD

Congestive Heart Failure - ACE inhibitors demonstrate a class effect for treatment of patients with CHF

Congestive Heart Failure - Abnormal electrocardiograms linked to heart enlargement

Congestive Heart Failure - NO production and release is progressively impaired in long-term CHF

Congestive Heart Failure - U.S. FDA approval to begin trial for left ventricular assist system granted

Coronary Artery Bypass Surgery - Gender a factor in who gets bypass surgery

Coronary Artery Bypass Surgery - Treatment of combined carotid and coronary artery disease reviewed

Coronary Artery Disease - Predictors of mortality were history of congestive HF, depressed HR variability

Coronary Artery Plaque - Protocol for measuring coronary artery plaque provides high-quality results

Decompensated Heart Failure - More research is needed before nitroglycerin can be a standard therapy for ADHF

Deep Vein Thrombosis - European Commission grants license for use of ARIXTRA to prevent VTE

Depression - Physicians must be alert for mood disorders in elderly who have lost a spouse

Diabetes - Minorities with diabetes at increased risk for heart disease, stroke

Diabetes Therapy - Recent findings in diabetes therapy provide new insights

Diagnostic Imaging - Postprocessing tools provide a means for quantifying microcirculation

Diagnostics - Researchers describe findings in diagnostics studies

Diet & Nutrition - Kellogg to develop products fortified with heart-healthy compound

Disease Prevention - Patients active in their healthcare may lower heart disease risk

Drug Development - Novel MAb fragment alters M2 muscarinic acetylcholine receptor activity

Drug Safety - European regulatory body announces action on COX-2 inhibitors

Echocardiography - Hand-held ECG systems can facilitate bedside diagnosis and patient screening

Echocardiography - Left atrial diameter may serve as criterion for HF with pulmonary congestion

Echocardiography - Real-time 3-dimensional echocardiography has a role in measuring stroke volume

Endocrinology - L-thyroxine therapy improves lipid-based CVD risk in subclinical hypothyroidism

Endocytosis - Keratinocyte growth factor receptor studied, role of tyrosine residue revealed

Environmental Health - Passive smoking kills 30 people a day in the U.K.

Finance - Biotechnology company reports 2004 annual financial results

Finance - Cardio-focused medical devices company reports Q4, year ended December 31, 2004

Finance - Cardiology instrument maker reports Q4 and year end 2004 financial results

Finance - Cardiovascular therapy developer raises $40.8 million in private funding round

Finance - Cryotherapy company reports 28% increase in revenue over Q1 2004

Finance - DX-88 and DX-890 maker reports increased net loss

Finance - Maker of device to treat venous reflux disease reports Q4 2004 financial results

Finance - Pharmaceutical company hires banking firm to identify partners, investors

Ganglionitis - Study inventoried immune competent cells in rat cardiac ganglia

Gene Silencing - RNA interference selectively silences angiotensin receptor subtype 1a

Health Promotion - Expert cautions against FDA approval of "race-based" pharmaceutical

Healthcare Coverage - Insurance company enhances critical illness, short term disability products

Heart Disease - Pharmaceutical company announces final results from CLEAR Platelets trial

Heart Disease Prevention - Growing evidence supports focus on mind-body connection in heart disease

Heart Failure - AT1 -receptor blockers have a valuable role in managing heart failure

Heart Failure - Beta-adrenergic receptor-blockers are a cornerstone in managing heart failure

Heart Failure - CPU 86017 improved cardiac performance in acute and chronic heart failure

Heart Failure - Candesartan had favorable effect across broad spectrum of heart failure patients

Heart Failure - Candesartan is an important treatment in chronic heart failure

Heart Failure - Focus on symptomatic relief leads to underuse of ACE inhibitors, beta-blockers

Heart Failure - Lack of trials limits application of differences in B-adrenoreceptor antagonists

Heart Failure - U.S. FDA approves candesartan cilexetil for the treatment of heart failure

Hemodialysis - Access monitoring does not improve outcome

Hemodialysis - Trial will compare hemodiafiltration with hemodialysis with respect to CV issues

Histamine Receptors - Norepinephrine exocytosis analyzed, nature of attenuation clarified

Hormone Replacement Therapy - HRT may improve oxidative stress and lipoprotein metabolism in older women

Hypertension - AT-II agonists facilitate systolic BP control and provide CV protection

Hypertension - Increased BP mediated partly by endothelin and ETAR in older female rats

Hypertension - More than 300 new hypertension genes discovered

Hypertension - Patients with malignant phase hypertension have significant cardiac hypertrophy

Hypertension - Reports add new data to hypertension research

Hypertension - Small increase in systolic BP may increase the burdens of CV disease

Hypertension Therapy - Efficacy of triple vasopeptide inhibition determined

Hypertrophy - GRKs may be involved in remodeling of cardiac myocytes

Hypoxia - Long-term hypoxia may program the fetus for cerebrovascular disease as an adult

Hypoxic-Ischemic Injury - Effects of hypothermia in neonatal encephalopathy were moderate

Imaging - Recent advances generate interest in PET to evaluate an array of CV diseases

Implantable Defibrillators - Review on implantable defibrillators highlights risk assessment

Interleukins - Normal platelets possess the soluble form of IL-6 receptor

Ischemia - Hippocampal forebrain ischemia analyzed, XIAP and Smac/DIABLO regulation defined

Ischemia/Reperfusion - Study investigated effects of sildenatil citrate on ischemia reperfusion injury

Ischemic Heart Disease - Climate-based health forecasts could aid coping with harsh winter health effects

Leptin Studies - Assay of renal Na+-ATPase and regulation in obesity conducted

Lipid Research - Lipid profiles improve in gene-deficient mice after cell therapy

Magnetic Resonance Angiography - MR angiograms were useful in detecting shunt patency, stenosis, and aneurysm

Magnetic Resonance Angiography - Technical developments in MRA have addressed many issues of imaging in children

Mergers & Acquisitions - Nutraceuticals company acquires 100% interest in Wellness Watchers Systems, LLC

Metabolic Syndrome - Researchers' data advance metabolic syndrome research

Mycobacterium Xenopi Infection -  Mycobacterium xenopi infection developed following heart transplantation

Myocardial Infarction - African Americans receive less aggressive heart attack treatment

Myocardial Infarction - Matrix-embedded marrow cells generate new vessels in ischemic hearts

Myocardial Infarction - Myocardial tissue inhibitors of MMPs play regulatory role in post-MI remodeling

Myocardial Infarction - Pregnancy-related heart attack incidence increases slightly in California

Myocardial Infarction - Survey shows higher percentage of women aware of heart attack signs than in 2004

Myocardial Infarction - Widely used artery clearing device does not help patients during heart attack

Myocardial Infarction - York academics study cardiac rehab shortfall

Myocarditis - IFN-gamma (KO) mice have greater progression to dilated cardiomyopathy and HF

Myocarditis - Reducing Th1-mediated autoimmune diseases may exacerbate common viral infections

Myocytes - Ginkgo biloba extract is nonselective cation channel modulator in cardiomyocytes

Natural Products - San-Huang-Xie-Xin-Tang studied, effect on hypotension and inflammation shown

Obstetrics - Renal clearance of atenolol and creatinine is increased during pregnancy

Obstetrics - Two DDAH1 haplotypes associated with susceptibility to preeclampsia

Obstetrics - U.S. FDA clear new fetal-health device

Obstructive Sleep Apnea - Obstructive sleep apnea is underdiagnosed and underappreciated in health care

Osteoporosis - Recent findings in osteoporosis provide new insights

Patents - Patent application filed with U.S. PTO for new format of PREVU* Skin Sterol Test

Patents - Pharma company announces new patents

Patents - Pharmaceutical company updates patent litigation regarding antiplatelet drug

Peripheral Arterial Disease - Company begins phase II gene transfer trial for peripheral arterial disease

Peripheral Arterial Disease - Nonsurgical cryotherapy to treat blocked leg arteries is promising, data show

Peripheral Arterial Disease - Review of lipid therapy focuses on functional improvement and symptomatic relief

Personnel - Peter Crosby named chief operating officer by cardiac device company

Physiology - SERCA2a calcium pump mRNA stability studied, role of specific domains revealed

Platelets - Alteplase inhibits platelet aggregation more than tenecteplase and reteplase

Platelets - Enhanced platelet activation occurs in colorectal cancer patients

Platelets - Sildenafil studied, effect on human platelet secretory function clarified

Preeclampsia - LMW heparin therapy lowers recurrence rate, provides additional benefits

Preeclampsia - S-nitrosoalbumin-mediated relaxation is enhanced by ascorbate and copper

Proteomics - Findings in proteomics provide new insights

Receptor Studies - Receptor activation minimizes signaling which leads to hypertrophic responses

Receptor Studies - Review focuses on in vivo models that investigate adenosine receptors

Receptor Studies - Studies have identified protease-activated receptors in vasculature and heart

Receptor Studies - Study investigated the effect of AT2 on myocyte contractile function

Sleep Apnea - Obstructive sleep apnea treatment receives CE Mark, European clearance

Stroke - Enrollment begun in study of relationship atrial high rate episodes and stroke

Stroke - National Stroke Association stroke prevention guidelines offered by center

Surgical Technology - Positive reaction to femoral puncture closure device, developer reports

Thromboembolism Therapy - Dalteparin based on body weight safe for thromboembolism in obesity

Thymectomy - Thymectomy disturbs long-term maintenance of lymphocyte populations

Tobacco Use - At least two central Nebraska hospitals to ban smoking on grounds

Tobacco Use - E.U. launches anti-smoking campaign targeted at young

Tobacco Use - First global anti-smoking treaty becomes binding international law

Tobacco Use - Mississippi coalition urges lawmakers to revive cigarette tax bill

Transdermal Drug Delivery - Efficient iontophoretic timolol transport achieved in vitro

Type 2 Diabetic Glomerulosclerosis - Local prosclerotic IGF-I system may reduce ER-mediated protection against GS

Vascular Smooth Muscles - Contraction of vascular smooth muscle studied, role of ERK1/2 clarified

Vascular Smooth Muscles - Vascular smooth muscle cell motility studied, influence of STAT-3 revealed

Vasoconstriction - Study examined the pH sensitivity of P2X receptors

Venous Reflux - Article reports positive result for Closure procedure

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