Cardiomyopathy
Researchers shed light on the mechanisms of lipotoxic cardiomyopathy
Published in Cardiovascular Week, April 11th, 2005
According to recent research published in the American Journal of Physiology - Endocrinology and Metabolism, "In obese rodents, excess myocardial lipid accumulation (lipotoxicity) of myocardium may cause cardiomyopathy that in the obese Zucker diabetic fatty (ZDF) fa/fa rat can be prevented by treatment with troglitazone (TGZ)."
M.Y. Wang and associates wrote, "To determine the underlying mechanisms, we measured total 5'-AMP-activated kinase (AMPK) protein and its activated, phosphorylated form, P-AMPK."
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Source: Cardiovascular Week (2005-04-11)
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