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HIV/AIDS-Related Dyslipidemia

HAART reduces VLDL and IDL apoB catabolic rate in patients with dyslipidemia

Published in Cardiovascular Week, April 25th, 2005

HAART reduces the VLDL and IDL apoB catabolic rate in HIV-1-infected patients with dyslipidemia.

"The relationship between antiretroviral treatment of HIV infection, body fat distribution, insulin resistance, and very-low-density lipoprotein (VLDL) and intermediate-density lipoprotein (IDL) apolipoprotein-B (apoB) kinetics was investigated in 55 HIV-infected patients taking two nucleoside analogs plus either a protease inhibitor (n=15) or a non-nucleoside reverse transcriptase inhibitor (n=25), 15 antiretroviral therapy-naive patients, and 12 HIV-negative controls.

"Compared with the controls, high-density lipoprotein cholesterol was reduced in all...

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