Chagas Disease

Cruzain inhibitors will aid in developing agents for treating Chagas disease

Published in Cardiovascular Week, May 16th, 2005

A recent report describes the development of alpha-keto-based inhibitors of cruzain, a cysteine protease implicated in Chagas disease.

According to recent research published in the journal Bioorganic & Medicinal Chemistry, "Trypanosoma cruzi, a protozoan parasite, is the causative agent of Chagas disease, a major cause of cardiovascular disease in many Latin American countries. There is an urgent need to develop an improved therapy due to the toxicity of existing drugs and emerging drug resistance. Cruzain, the primary cysteine protease of T cruzi, is essential for the survival of the parasite in host cells and therefore is an important target for...

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Source: Cardiovascular Week (2005-05-16)

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