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Cardiovascular Week

Susan Hasty, Publisher

Table of Contents . . . June 6th, 2005

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Cardiovascular Week | Other Publications

Angiotensin - AT1 -Mas complex could be target for intervention in CV diseases

Cardiovascular Risk Factors - Occurrence of one CV risk factor may increase likelihood of others

Hyperlipidemia - Statins and n-3 fatty acids are the most favorable lipid-lowering interventions

Stents - Intraoperative stent placement avoids patch augmentation of pulmonary vessels

Addiction Medicine - Nicotinic acetylcholine receptor channel studied, subunit modulation shown

Alzheimer Disease - Study finds statin drugs can help treat Alzheimer disease

Angiology - Recent findings illuminate research in angiology

Angiology - Researchers provide details of new studies and findings in the area of angiology

Angiology - Study shows association of carotid intima-media thickness and coronary events

Angioplasty - Study assessed filter protection devices during angioplasty and stenting

Angiotensin - Researchers describe findings in angiotensin studies

Apoptosis - ARD1-NATH protein acetyltransferase identified and characterized

Aspirin Therapy - Stop aspirin therapy before procedures only if bleeding risk is serious concern

Atherosclerosis - Angiotensin plays role in loss of heparan N-sulfotransferase in liver

Atherosclerosis - CXCL16 is involved in enhanced stenosis in atherosclerotic coronary arteries

Atherosclerosis - Studies describe new findings in atherosclerosis research

Atherosclerosis - Diabetes gene associated with subclinical atherosclerosis

Atherosclerosis - Insulin resistance impairs endothelial function in healthy men

Atherosclerosis - Mitochondrial dysfunction may be early step leading to atherosclerotic disease

Atherosclerosis - New findings in atherosclerosis described

Atherosclerosis - Tibolone associated with upregulated expression of estrogen and LDL receptors

Cardiology - New findings in the area of cardiology described

Awards - State of Ohio awards clinic-led consortium $32.8 million for 3 research units

Behcet Disease - The carotid-femoral pulse wave velocity is not increased in Behcet disease

Biochemistry - PI3K gamma contributes to the control of cAMP levels in the cardiac system

Business Update - Commercialization, R&D alliance with Biovail in cardiovascular area announced

Business Update - Company announces product launch with Kesko of Finland

Business Update - Company receives CE Mark approval for UniStar cobalt chromium stent

Cardiology - Reports describe recent advances in cardiology research

Cardiac Development - Mechanism regulates Nfatc1 expression in developing cardiac valves

Cardiac Surgery - Long-term outcomes in repair of transposition of great arteries are encouraging

Cardiac Surgery - Manouguian patch enlargement procedure is useful during double valve replacement

Cardiology - Cardiac monitoring systems and services company cites supporting research

Cardiology - Cardiac rehabilitation program is accompanied by very low incidence of CV events

Cardiology - Complement activation may be related to necrosis within the myocardium

Cardiology - Research in cardiology provides new insights

Cardiology - Cost-effectiveness of in-home automated external defibrillators determined

Cardiology - Demonstration of cardiac myocyte differentiation challenges common view

Cardiology - Diagnosis and management of cardiac tumors discussed

Cardiology - Long-term treatment for C. pneumoniae did not reduce the rate of CV events

Cardiology - Medical device company announces cardiopulmonary industrial integration plan

Cardiology - Mitral valve repair in children provides acceptable long-term results

Cardiology - Researchers' data advance cardiology research

Cardiology - New data illuminates research in cardiology

Cardiology - Premature ventricular complexes from RV outflow tract may cause LV dysfunction

Cardiology - Pressure monitoring cannot reliably detect catheter migration

Cardiology - Programming implantable cardioverter defibrillator reduces shocks, study shows

Cardiology - RV dilatation is highest in patients with pulmonary artery embolism

Diabetes Therapy - Reports add new data to diabetes therapy research

Cardiomyocytes - New research in the area of cardiomyocytes detailed

Cardiomyopathy - Role of gene microarrays in cardiomyopathy research reviewed

Cardioprotection - KR-32570 possesses potent cardioprotective effects in perfused rat hearts

Imaging - Researchers' data advance imaging research

Cardioprotection - Recent findings in cardioprotection described

Cardioprotection - Review explains concepts of hypothermia-associated neuro- and cardioprotection

Cardiopulmonary Bypass - Nitric oxide gas and iloprost reduces platelet dysfunction during CPB

Cardiopulmonary Resuscitation - Novel probe provides ultrafast PO2 measurement

Cardiothoracic Surgery - Outcome after heart and heart-lung transplantation evaluated

Cardiovascular Disease - Cardiovascular effects of endomorphins in diabetic rats reported

Cardiovascular Disease - Effects of diabetes on Kv channels in coronary muscle cells studied

Cardiovascular Disease - Inhibition of GGTase I may be useful for treating cardiovascular diseases

Cardiovascular Disease - O2 - scavenger reverses abnormalities in Eng+/- arteries

Cardiovascular Disease - Study suggests pioglitazone HCl reduces carotid artery intima-media thickness

Cardiovascular Disease - Telemedicine systems company and St. Jude Medical expand alliance

Cardiovascular Disease - Trial using noninvasive cardiovascular risk assessment technology announced

Cardiovascular Disease Prevention - Hormone replacement therapy reduces left ventricular mass

Cardiovascular Health - Ob-gyns have important role in helping women prevent heart disease

Cardiovascular Research - Apnea training explained greater oxygen conservation seen in divers

Cardiovascular Research - Increased aortic distensibility in athletes may cause better diastolic function

Cardiovascular Research - Resistance training is associated with cardiac hypertrophy and lower BP

Cardiovascular Research - Study compared influences of antianginal drugs on CV response to orthostasis

Cardiovascular Risk Factors - Waist-to-height ratio better identifies youth with CV risk factors than BMI

Cerebral Perfusion - Arch repair with antegrade cerebral perfusion has several advantages

Chronic Renal Failure - Impaired antioxidant defense system has role in pathogenesis of oxidative stress

Collaborations - Swiss companies sign agreement to produce drug to treat pulmonary disease

Community Health Programs - Study provided information about organizational involvement in health activities

Coronary Artery Bypass Grafting - Perioperative RBC transfusion linked to increased mortality risk

Coronary Artery Disease -  MEF2A mutations are not a common cause of coronary artery disease

Coronary Artery Disease - Ankle-brachial index is inversely related to prevalence coronary artery disease

Coronary Artery Disease - Intensive atorvastatin is not more beneficial than diet and low-dose lovastatin

Coronary Artery Disease - Perindopril lowers BP, decreases arterial stiffness and central pulse pressure

Coronary Heart Disease - Erythrocyte sedimentation rate predicts coronary heart disease in males

Cyclosporin - Study evaluated effects of cyclosporin A on cardiomyocytes

Deep Vein Thrombosis - Company provides update on FIBRIMAGE development program

Depression - Atherosclerosis boosts risks of depression in elderly

Diabetes Therapy - Atorvastatin significantly reduces vascular events in diabetes

Diabetes Therapy - Findings in diabetes therapy provide new insights

Diabetes Therapy - Pioglitazone restores endothelial function in aorta of diabetic rats

Diagnostics - BNP and NT-proBNP may be equally useful in diagnosing CHF in dyspnea ED patients

Diagnostics - Findings in diagnostics provide new insights

Diagnostics - MRI has potential to become the future CV 'all-round examination'

Diet & Health - Health-conscious people have reduced mortality compared with general population

Diet & Nutrition - Cranberries full of antioxidants, study says

Diet & Nutrition - High-dosage vitamin E supplements should be avoided

Diet and Nutrition - Tea catechins are cardioprotective in people with type 2 diabetes

Disease Screening - Anthropometric indices are markers of CVD risk factors in Singaporean women

Down Syndrome - Subjects with Down syndrome showed blunted heart rate response to upright tilt

Drug Development - Positive Aggrastat injection strategy trial data published

Drug Development - Scottish Medicines Consortium accepts therapy for heart failure in LVSD patients

Drug Development - U.S. FDA grants approval for Adenosine

Drug Development - U.S. FDA grants approval of formulation for cardiovascular product fenofibrate

Echocardiography - Dobutamine stress real-time myocardial contrast ECG is safe and feasible

Echocardiography - Doppler tissue dynamics may complement flow velocity in evaluating LAA function

Echocardiography - Method is more effective than BNP level in detecting high risk for LV remodeling

Echocardiography - TEE may be dispensable when small vessel disease is the presumed stroke etiology

Echocardiography - Tissue Doppler imaging is more accurate than propagation velocity

Echocardiography - Wall-thickness measurement may improve sensitivity of dobutamine stress ECG

Embolism - Clinical outcome of patients with venous thromboembolism transcribed

Endocytosis - Phosphoinositide phosphatase studied, role in endocytosis clarified

Erectile Dysfunction - Review provides practical approach for managing ED in primary care

Exercise and Health - H-1 receptor-mediated vasodilatation contributes to postexercise hypotension

Finance - Biotechnology company reports financial results for first quarter of 2005

Finance - Corporation reports merger partner's financial results for first fiscal quarter

Finance - Implant technology company announces 1Q 2005 financial results

Finance - Pharmaceutical company receives filing extension from NASDAQ Stock Market

Finance - Pharmaceutical company reports 63% increase in revenue, net growth of 227%

Finance - Study will explore sex, gender and heart disease

Healthcare Coverage - Company announces new CMS outpatient reimbursement codes for VAD supplies

Heart Bypass Surgery - Automated proximal anastomoses linked to reduced graft patency

Heart Disease - Lower triglyceride levels may be a more optimal cutpoint in CHD risk assessment

Heart Disease - Oxidation/antioxidation balance can be a good metabolic ischemia indicator

Heart Disease - Patients with inflammation may have greater benefit from statin therapy

Heart Disease - Serum uric acid levels are unlikely to predict coronary heart disease

Heart Disease Risk Factors - Abnormal heart scans predict higher risks for African Americans, Hispanics

Heart Disease Therapy - New discovery sparks hope of safer dosage of warfarin

Heart Failure - Angiotensin-receptor blockers are important in pharmaceutical management of HF

Heart Failure - Atrial pacing and sensing during CRT characterized

Heart Failure - Predischarge BNP and E/Ea are incremental predictors of outcome in heart failure

Hemodialysis - Sevelamer decreased total- and LDL-cholesterol, calcium in hemodialysis patients

Hemodialysis - Vascular tone and LV function appeared to be impaired by dialysis procedure

Homocysteine - Plasma Hcy concentration varied with ontogenic development in rats

Hormone Replacement Therapy - New guidelines say no estrogen for postmenopausal women who've had hysterectomy

Hormones - Contact of estrogen with cells could be a sensor for receptor signaling

Hypercholesterolemia - Statin therapy cost-effective for a wider range of individuals

Hypertension - 17 beta-estradiol improves vasodilatory responses in mildly hypertensive women

Hypertension - Cyclooxygenase-2 vasoconstrictor prostanoids studied, role of hypertension shown

Hypertension - Findings advance knowledge in hypertension research

Hypertension - High overnight blood pressure linked to increased blood sugar levels

Hypertension - Patients do not recognize importance of elevated SBP or status of BP control

Hypertension - Procollagen propeptide examined, relationship to strain in hypertension shown

Hypertension - Regular physical fitness not enough for patients with severe hypertension

Hypertension - White-coat effect is virtually eliminated using new device

Hypertension Genomics and Genetics - GNAS1 gene variant associated with hypertension

Imaging - Research add new data to imaging body of knowledge

Imaging - Significant noncoronary findings found during heart CT scans

Imaging - Treadmill exercise 82Rb PET provides imaging results of superior quality

Infective Endocarditis - Patients with active infective endocarditis have high-risk profile

Information Technology - Online Inpatient Medical Services company renames disease management services

Ischemia - Ischemic preconditioning examined, effect on behavioral deficits clarified

Ischemia - Studies advance knowledge in ischemia research

Ischemia/Reperfusion - Hsp20 may constitute a new therapeutic target for ischemic heart diseases

Left Ventricular Systolic Dysfunction - White and nonwhite patients have similar prevalence of LV systolic dysfunction

Lipid Studies - Dyslipidemia of diabetes reviewed

Lipoproteins - Combination regimen to increase HDL cholesterol may prevent CV events

Lipoproteins - Linoleic acid suppresses secretion of atherogenic lipoproteins HepG2 liver cells

Liver Cancer - PORT-A-CATH II RDD Arterial Access System receives U.S. FDA clearance

Lung Cancer - Cardiopulmonary exercise tests predicted lung cancer surgical outcome

Marfan Syndrome - Regression model with aortic parameters only can predict Marfan syndrome

Medical Devices - CE Mark granted for embolic protection filter

Medical Devices - CE Mark granted for three drug-eluting stent systems

Medical Devices - Cardiovascular system-focused company introduces new lead locking device

Medical Devices - Medical technology company launches spot blood pressure monitor

Medical Devices - Monitoring system reduces low blood pressure 52% in women undergoing C-section

Mergers & Acquisitions - Company closes transaction with IMAGIN Diagnostics Centres Corp.

Metabolic Syndrome - Research reveals metabolic syndrome is becoming nation's costliest concerns

Metabolism - Study evaluated combined sevelamer and calcium carbonate on mineral metabolism

Multivessel Coronary Disease - Pressure-derived fractional flow reserve is valuable tool in multivessel disease

Myocardial Infarction - Beta2 adrenergic receptor gene polymorphisms were associated with risk of MI

Myocardial Infarction - Clue may explain mystery of emotionally triggered sudden cardiac arrest

Myocardial Infarction - Diabetes appears to rob women of usual advantage in heart disease risk

Myocardial Infarction - Findings emphasize the relationship between life events and acute MI

Myocardial Infarction - MMP activity studied, imaging after myocardial infarction reported

Myocardial Infarction - No difference in LVEF was observed when carvedilol was compared with atenolol

Naproxen - Naproxen interfered with inhibitory effect of aspirin on platelet COX-1 activity

Nitric Oxide - D/L-nebivolol produced hemodynamic changes

Nutrition - Low-fat dairy may lower risk of type 2 diabetes in men

Obesity - Exercise organization backs Clinton, heart association anti-obesity campaign

Orthopedics - Preclinical evaluating CORTOSS with artificial disc implantation presented

Patents - Drug delivery company awarded patent for multidose dry powder drug packages

Patents - Medical device company awarded patent for embolization device

Patents - New patent issued to University of Pennsylvania for hyperlipidemia treatment

Patient Management - Discharge within 24 hours after onset of acute chest pain can be safe

Percutaneous Cardiac Intervention - Outcome of repeat percutaneous balloon mitral commissurotomy evaluated

Peritoneal Dialysis - Hypoalbuminemia can have harmful effects in peritoneal dialysis patients

Personnel - Rolf Hanggi to appointed to board of directors of biopharmaceutical company

Platelets - Platelet activation examined, influence on complement system defined

Platelets - Platelet activation studied, induction by acyl-phosphatidylcholines clarified

Pollution - Paper presents analysis of variations of PM10 and PM2.5 levels

Primary Aldosteronism - Patients with primary aldosteronism experienced more CV events than HT patients

Proteomics - Mice with a conditional mutant BMP type II receptor allele model human disease

Proteomics - Reports advance knowledge in proteomics research

Public Health - Community-based Tai Chi program produces beneficial effects

Pulmonary Arterial Hypertension - PulmoLAR granted orphan drug status by U.S. FDA

Pulmonary Hypertension - Simvastatin treatment appears safe in patients with pulmonary hypertension

Restenosis - Drug-releasing stents showing higher complication rate than trials indicated

Sepsis - NAC does not influence microalbuminuria/creatinine ratio in clinical sepsis

Sleep Apnea - CPAP therapy in patients with sleep apnea and HT did not decrease BP and HR

Sleep Research - Depression was most important factor associated with persisting sleep symptoms

Statins - Atorvastatin appears to have an acute protective effect that wanes with time

Statins - Researchers describe findings in statins studies

Statins - Study identified new in vivo targets of atorvastatin treatment

Stents - Percutaneous pulmonary valve implant is successful addition to surgical program

Stroke - Data: Cerovive demonstrates a reduction in disability in stroke patients

Stroke - In cases of high comorbidity, clopiclogrel may be better choice than aspirin

Stroke - Surgical robot helps reduce stroke in high risk atrial fibrillation patients

Surgical Technology - CYPHER Stent studies demonstrate strong results in diabetic patients

Surgical Technology - Medical company receives FDA clearance for introducer sheath

Systemic Sclerosis - Some systemic sclerosis patients were prone to develop skeletal myopathy

Thrombosis - Factor V Leiden analyzed, role in thrombosis and atherosclerosis clarified

Thrombosis - Fluorogenic substrate evaluated, potential in ADAMTS13 assay indicated

Transcription Factor -  Xenopus laevis Pod 1 is nearly 85% similar to other vertebrate homologues

Transplant Medicine - Therapy combination prolongs cardiac allograft

Trends - ECG monitoring products, services continue to save the day for cardiac patients

Vascular Disease - Quality, not quantity, of repair cells key to blood vessel health

Ventilation - Positive-pressure elevation did not produce hemodynamic changes in children

Viral Cardiomyopathy - Endothelial dysfunction of coronary microcirculation has variety of impacts

Weight Loss - Obesity severity limits cardiovascular benefits of weight reduction

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