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Cardiovascular Week

Susan Hasty, Publisher

Table of Contents . . . September 5th, 2005

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Cardiovascular Week | Other Publications

Alzheimer Disease Risk Factors - Extensive peripheral atherosclerosis may be a risk factor for Alzheimer disease

Aspirin - Low-dose aspirin increases aspirin resistance in patients with CAD

Cardiovascular Risk Factors - Use of low-dose OCs increases risk of cardiac and vascular events

Imaging - Technology successfully demonstrated CV circulation in 4-D

Statins - Pravastatin reduced rate of kidney function loss

Abdominal Aortic Aneurysm - Doppler ultrasound may be useful in classification

Abdominal Aortic Aneurysm - Efficacy of endovascular repair evaluated

Ablation - Noncontact and electroanatomic mapping is useful in complex ablations

Amyotrophic Lateral Sclerosis - Recent findings in amyotrophic lateral sclerosis provide new insights

Aneurysm Surgery - Postoperative changes in cerebral metabolism characterized

Aneurysms - Hospital offers minimally invasive treatment for thoracic aortic aneurysms

Atherosclerosis - Research add new data to atherosclerosis body of knowledge

Angina - Action of nitroglycerin for chest pain may place some patients at risk

Angiogenesis - Research describes tumor suppressor activity of PTEN

Angiography - Multislice CT angiography is noninvasive diagnostic procedure

Angiography - Results highlight the limitations of 2D angiography

Angiology - Technique is promising for recanalizing difficult total occlusions

Atherosclerosis - Researchers' work adds to atherosclerosis body of knowledge

Angioplasty - Outpatient PTCA is safe and feasible for many in a routine population

Angioplasty - Quality improvement analysis can expedite care for PCI patients

Angioplasty - Recent studies add new data to angioplasty research

Angiotensin - During ACE inhibition ANG-(1-7) can be stimulated by sodium restriction

Annular Dilatation - Leaflet length is used to quantify severity of mitral regurgitation

Antioxidant - Flavonoids may promote cell survival as potent antioxidants

Cardiology - Reports advance knowledge in cardiology research

Arteriosclerosis - Prothymosin alpha linked to transplant arteriosclerosis

Atherosclerosis - Antioxidant NAC can reduce atheroma progression

Atherosclerosis - Fluorescence spectroscopy and detecting inflammatory cells in blood vessels

Atherosclerosis - Low-density lipoproteins and lipoprotein lipase in diabetes reviewed

Atherosclerosis - More is better, at least in angioplasty

Atherosclerosis - Reports describe recent advances in atherosclerosis research

Cardiology - Studies add new findings to cardiology body of knowledge

Atrial Fibrillation - Endocardial radiofrequency ablation effective during mitral valve surgery

Atrial Fibrillation - Guidelines focus on postoperative atrial fibrillation

Awards - Macugen pegaptanib sodium injection named Innovative Pharmaceutical Product 2005

Echocardiography - Reports describe recent advances in echocardiography research

B-type Natriuretic Peptide - Anemia may confound the relationship between BNP, cardiac function & prognosis

Blood Pressure - ACE genotype linked to blood pressure abnormalities in type 1 diabetes

Blood Pressure - Doxazosin controls hypertension and albuminuria in diabetic patients

Brain Cancer - 3D contrast-enhanced MR venography valuable surgical planning tool

Business & Finance - Gene-transfer company reports Q2 financial results, updates GENASIS trial

Business & Finance - Medicare reimbursed products provider reports 422% revenue increase in 3 months

Echocardiography - Studies describe new findings in echocardiography research

Business & Finance - Pharma company receives phase II SBIR award for neuroinflammation

Business Update - Automated electrophysiology procedure complete

Business Update - Cardiology instrument systems maker reports second quarter 2005 results

Business Update - European biopharma awards $1.9M for cardiac safety monitoring and services

Business Update - Reimbursement increased for external ventricular assist devices

C-Reactive Protein - Study describes mechanism underlying effect of CRP on vascular system

Cancer Prevention - Non-steroidal anti-inflammatory drugs used for prevention of cancer

Cancer Therapy - Flavopiridol shows promise as an anticancer treatment

Cardiac Ablation - Adapter was effective in epicardial RFA in a beating heart

Cardiac Aging - Measures of cardiac function may be a useful index of normal cardiac aging

Cardiac Allograft Vasculopathy - Dobutamine MPI reliably identifies risk for subsequent cardiac events

Cardiac Arrest - Impedance threshold device improves blood pressure during CPR

Cardiac Arrest - Novel probe provides ultrafast PO2 assessment during CPR

Cardiac Development - Changes affecting signaling pathways can result in severe heart defects

Cardiac Pacemakers - Non-equilibrium behavior of HCN channels characterized

Cardiac Sarcoidosis - 18F-FDG PET valuable tool in diagnosis

Cardiac Surgery - Neurologic monitoring enables cardiac surgical teams to prevent brain injury

Cardiac Surgery - Optimizing cerebral oxygen saturation may improve outcome of cardiac surgery

Cardiac Transplantation - Caspase-3 inhibition may be useful strategy for preventing graft CAD

Cardiac Transplantation - Circulating T cells may predict development of endothelial dysfunction

Cardiac Transplantation - Citrate synthase autoantibodies may have role in allograft vasculopathy

Cardiac Transplantation - Regurgitation after heart transplant is often due to number of biopsies

Cardiology - Diovan approved for new indication

Cardiology - First of two pivotal phase 3 studies of regadenoson met its primary endpoint

Cardiology - Inferoposterior bundle may be anatomic substrate for conduction

Cardiology - New findings in the area of cardiology detailed

Cardiology - Ratio of cardiac output and body size is driving factor in CV allometry

Cardiomyocytes - CGRP has different mode of action on developing cardiomyocytes

Cardiomyocytes - IL-18 reduces the responsiveness of the myofilaments to Ca2+

Cardiomyopathy - Collaboration studies effects of thymosin beta 4 on degenerative muscle diseases

Cardiopulmonary Bypass - Changes in pulmonary blood flow affect slopes of single-breath test.

Cardiopulmonary Bypass - Plasma cortisol levels with maximal anti-inflammatory effects determined

Cardiopulmonary Resuscitation - Stored wet-primed ECMO circuits maintain function for 2 weeks

Cardiovascular Devices - Mitral mechanical replacement proves safe for pregnant women

Cardiovascular Disease - Cardiac function impaired in hypertensive patients with type 2 diabetes

Cardiovascular Disease - DNA vaccine with receptor coding plasmids impair cardiac function

Cardiovascular Disease - High risk patients are best served by aggressive cholesterol-lowering therapy

Cardiovascular Research - Cardiac cycle modulation is expressed in respiratory motor activity

Cardiovascular Research - Glycerol can be effective hyperhydrating agent during cold-air exposure

Cardiovascular Research - Pathogenesis of vascular calcification in chronic kidney disease

Cardiovascular Research - Report describes a model of CV gas bubble transport

Cardiovascular Research - Study provides insights into possible mechanisms of TMP in the vascular system

Cardiovascular Risk Factors - Education mediates link between socioeconomics and CV risk factors

Cardiovascular Risk Factors - Inflammatory component of CV disease is reversible with smoking cessation

Choline - Choline intake may reduce cardiovascular disease risk

Chronic Heart Failure - CHF results in alterations of Na+-K+-ATPase

Chronic Obstructive Pulmonary Disease - Protective effect of being female is lost in COPD patients

Circulation - Raman-based assay measures microvascular oxygenation

Clinical Assays - Study examined analytical performance of clinical vitamin B6 assays

Congenital Heart Disease - MRI cardiac catheterization poised for success in children

Congenital Heart Disease - Report describes radiofrequency catheter ablation for managing arrhythmias

Congestive Heart Failure - Heart failure worsens with anemia, increases risk of death

Congestive Heart Failure - New heart failure guidelines stress early diagnosis and treatment

Coronary Angioplasty - Perfusion area influences coronary flow velocity reserve

Coronary Artery Bypass - 80-year-olds should be given heart bypass surgery

Coronary Artery Bypass - Baseline CRP levels predict postoperative atrial fibrillation risk

Coronary Artery Bypass - Jugular bulb oxygen saturation well-maintained during off-pump CABG

Coronary Artery Bypass - Post-CABG neuropsychological outcomes characterized

Coronary Artery Disease - CAD is associated with impaired endothelium-dependent dilatation

Coronary Artery Disease - Link between cTnT and CAD stenosis does not vary with renal function

Coronary Artery Disease Assessment - PET/CT allows accurate noninvasive clinical decision-making about CAD

Diabetes Complications - PET predicts outcome in diabetic patients with ventricular dysfunction

Diabetes Epidemiology - Frequency of diabetes on death certificates in U.K. reported

Diabetes Pathogenesis - Inflammation and endothelial dysfunction markers increased in diabetes

Diabetes Therapy - Hyperglycemia has short-term adverse effects on myocardial blood flow

Diabetic Nephropathy - Podocyte injury is no latecomer in diabetic nephrology

Diabetic Neuropathy - Cardiac autonomic neuropathy prevalent in Vietnamese diabetic patients

Diagnostics - Report describes diagnosis and treatment of acute coronary syndrome

Diagnostics - Residents can use ultrasound imagers to identify aortic aneurysms

Diagnostics - Synchrotron radiation angiography detects in-stent restenosis

Diet & Nutrition - Data do not justify emphasis on nutrient supplements over food and diet

Diet & Nutrition - Dietary fat intake and early mortality patterns in Malmo analyzed

Diet & Nutrition - International conference held on healthy effect of virgin olive oil

Diet & Nutrition - Limiting cholesterol decreases lecithin intake in Japanese people

Diet & Nutrition - Nutrition may reduce symptoms of peripheral vascular disease

Disease Associations - Chronic kidney disease studied, pathogenesis of vascular calcification defined

Drug Development - Enrollment completed for phase III trial of pexelizumab

Echocardiography - Findings describe new data in echocardiography research

Electrocardiography - CTCA is a promising technique for detection of coronary artery stenosis

Emergency Medicine - Laryngeal tube enables airway management with minimal training

Endothelial Cell - Autologous endothelial cells mat be beneficial in treating vascular injury

Erythromycin - Effect of erythromycin might be due to inhibition of MMP-2 in VSMCs

Familial Hypercholesterolemia - Colestimide effective alone or with atorvastatin

Finance - $10 million grant supports research on inflammation's role in heart disease

Finance - Biopharma company announces financial results

Finance - Biopharmaceutical firm reports loss of $0.11 per share

Finance - Biotechnology company reports second quarter 2005 results

Finance - CNS-focused company announces second quarter 2005 results

Finance - Cell-focused biotechnology company reports Q2 2005 financial results

Finance - Device company reports 2005 earnings of $14.6 million

Finance - Medical device company announces first quarter gross margin of 70%

Finance - Vascular surgeons invest in device company, $3 million equity round closes

Fitness & Wellness - Cardiac function in twin pairs discordant for physical fitness examined

Fitness & Wellness - Methods to assess physical activity and physical fitness reviewed

Fitness & Wellness - SilverSneakers, aging council to promote physical activity for older adults

Folic Acid - Folic acid is effective supplement that targets large artery stiffness

Genomics - Studies advance knowledge in genomics research

Genotyping - Polymorphisms might be predictive markers of persons prone to CV diseases

Geriatric Cardiology - Unnecessary DDDR-70 pacing raises mortality risk in AICD users

HIV/AIDS & Acute Coronary Syndrome - Report highlights acute coronary syndrome in HIV-infected patients

HIV/AIDS Drug Side Effect - Efavirenz diminishes antilipid efficacy of HMG-CoA reductase inhibitors

HIV/AIDS Therapy - Vascular changes greater in HIV-infected children exposed to protease inhibitors

Head Trauma - Carotid artery stenting has poor outcome

Healthcare Disparity - Medical gaps narrowing between blacks and whites

Heart Disease - Interest increases in interventions that improve health-related QoL

Heart Disease Mortality - Policy should change to address heart disease population-wide

Heart Failure - Atrial pacing and sensing characterized during CRT

Heart Failure - Walk test has limited use to assess changes in patients with severe HF

Hypercholesterolemia - Reasons for suboptimal treatment of hypercholesterolemia are complex

Hypertension - BH4 may prevent development of hypertension and myocardial hypertrophy

Hypertension - Fat kids can bounce back to normal blood pressure

Hypertension - High salt induces activation of renin-angiotensin-aldosterone systems

Hypertension Therapy - Results of STRATHE study released

Hypertriglyceridemia - TRbeta may be a potential target for treatment of hypertriglyceridemia

Hypoxia - Mdm2 and HIF-1alpha combine to promote tumor cell adaptations to hypoxia

Imaging - Agreement with Novadaq Technologies finalized to service cardiac imaging system

Imaging - Automated analysis of strain rate is feasible and quick

Imaging - EBCT best for evaluating adults with congenital defects in the heart arteries

Imaging - MDCT calcium score can rule out myocardial ischemia detected by dobutamine CMR

Imaging - New findings in the area of imaging described

Imaging - Report describes a promising rejection marker for pediatric patients

Imaging - Review analyzes mechanisms underlying postsystolic motion

Imaging - Strain rate imaging can demonstrate small changes in deformation rate

Implantable Cardioverter Defibrillators - QRS duration was not useful to predict ICD benefit

Implantable Cardioverter Defibrillators - Report recommends technique for right atrial septal pacing insertion

Information Technology - Kentucky medical center installs cardiac, vascular cath labs inventory system

Interferon - CD4+ T-lymphocyte migration studied, signal cascade stimulation revealed

Interleukin-6 - IL-6 effects on cardiomyocyte hypertrophy could be mediated by Ang II

Ischemic Heart Disease Risk Factors - Hereditary hemochromatosis genotypes were not associated with ischemic HD or MI

Kidney Transplantation - Intrarenal resistance indices are associated with CV risk factors

Kidney Transplantation - Novel clip facilitates hand-assisted laparoscopic donor nephrectomy

Lipid Studies - Salvianic acid A may have potential against oxidative stress processes

Marketing - Medical marketing agreement signed for BioPatch wireless heart monitor

Medical Devices - U.S. FDA grants approval for Biocor stented tissue valve

Mergers & Acquisitions - Maternal-fetal physician services company acquires pediatric cardiology practice

Mergers & Acquisitions - Medical technology company acquires majority control of Rheologics Inc.

Metabolic Syndrome - Links between metabolic syndrome and insulin resistance investigated

Microsurgery - Microvascular anastomosis may be performed in hyperfibrinogenemia

Migraine Headaches - Several conditions have been noted to be comorbid with migraine

Myocardial Infarction - Catheter-based skeletal myoblast delivery shows promise

Myocardial Infarction - Inspra reduces risk of early death in heart attack patients with LVSD

Myocardial Infarction - Low HRV partially mediates effect of depression on survival after acute MI

Myocardial Infarction - Race and gender disparities persist in heart attack care and mortality

Myocardial Infarction - Report reveals high rate of heart attack among ethnic minorities in Scotland

Myocardial Infarction - Study analyzed the myocardial performance index

Natriuretic Peptide - Study evaluated NT-proBNP as a prognostic marker of cardiovascular morbidity

Neuroscience - Kynurenic acid production examined, role of homocysteine determined

Patents - Patent application filed for cardiovascular technology

Patents - U.S. patent issued for inducing angiogenesis by electrical stimulation of muscle

Pediatric Cardiology - Attenuated electrode pads enable pediatric AED use

Pediatric Cardiology - NT-proBNP and BNP are markers for heart disease in infants and children

Peripheral Arterial Occlusion - Clinical trial data of chronic peripheral arterial occlusion treatment published

Peripheral Neuropathy - Company inks agreement for treatment of diabetic neuropathy with VEGF-2

Personnel - Cardiovascular surgery device manufacturer elects member to board of directors

Pharmaceutical Research - Market research firm releases study on pharma spending

Pharmacology - Adrenomedullin examined, pulmonary pharmacology clarified

Physiology - Rhythmicity in arterial smooth muscle reviewed

Pituitary Gland - Cytosolic Cl- ions examined, pituitary melanotroph regulation clarified

Product Licensing - Product license agreement signed for antihypertensive agent ARB olmesartan

Progenitor Cells - Human mononuclear cells differentiate to EPCs at a very low rate

Proteomics - Study determined alterations that occur in the initial phase of RV hypertrophy

Proton-Pump Inhibitors - Study focused on proton-pump inhibitors and chest pain events

Pulmonary Arterial Remodeling - L-arginine can modulate pulmonary vascular matrix remodeling

Pulmonary Hypertension - European mutual recognition procedure for pulmonary hypertension treatment done

Receptors - Functional urotensin II receptors in human skeletal muscle myoblasts studied

Renal Transplantation - Reports advance knowledge in renal transplantation research

Sleep Apnea - Supine sleep increases frequency of apneas in Cheyne-Stokes patients

Sleep Disorders - Sleep disorders are often misdiagnosed or underdiagnosed

Statins - New findings in the area of statins described

Statins - Pravastatin induces regression of focal coronary atherosclerosis

Statins - Study identified new in vivo targets of atorvastatin treatment

Statins - The nature of statin neuromyotoxicity remains unresolved

Stents - Drug-eluting stent was associated with lower risk of restenosis

Stents - Recent findings in stents described

Stents - Stents are associated with exercise-induced coronary vasoconstriction

Stress - Treatment with alpha-tocopherol prevents stress-induced radical attack

Stress-Induced Fibrinogen - IL-6 reactivity was an independent predictor of stress-induced fibrin formation

Stroke - Alpha-1-antichymotrypsin is linked to post-stroke dementia

Stroke - ECG abnormalities in acute stroke and may predict 3-month mortality

Systemic Sclerosis - LV filling dysfunction is progressive in systemic sclerosis

Tumorigenesis - ING4 represses activation of the hypoxia inducible factor

Vascular Morphogenesis - Researchers recommend further study of vascular anomaly genes

Ventricular Arrhythmia - Effects of LVAD therapy evaluated

Ventricular Extrasystoles - Phase 2 reentry may be the responsible mechanism for ventricular extrasystoles

Ventricular Tachycardia - Effects of nifekalant on spiral excitations are reversed by lidocaine

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