Atherosclerosis

Fas ligand gene transfer increases vulnerability of atherosclerosis

Published in Cardiovascular Week, January 30th, 2006

Adenovirus-mediated Fas ligand gene transfer increased the vulnerability of pre-existing atherosclerosis in ApoE-deficient mice.

"The death receptor Fas and Fas ligand (FasL) are present in human advanced atherosclerotic plaques. The activation of the Fas/FasL pathway of apoptosis has been implicated in plaque vulnerability. In the present study, we investigated whether overexpression of FasL in pre-existing atherosclerotic lesions can induce lesion remodeling and rupture-related events," researchers in the Netherlands report.

"Carotid atherogenesis was initiated in apolipoprotein E-deficient mice by placement of a perivascular silastic collar. The...

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Source: Cardiovascular Week (2006-01-30)

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