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Pediatric Cardiology

Acetyl-L-carnitine may exert cardiac neurotrophic action

Published in Cardiovascular Week, January 30th, 2006

Acetyl-L-carnitine is suggested to have a neurotrophic action on the cardiac autonomic nervous system.

A recent report from Italy notes, "There is a higher incidence of sudden death in patients with Rett syndrome than individuals in the general population. Previous studies have implicated cardiac dysautonomia and a long QT interval as causative factors."

"Because carnitine plays a critical role in cellular metabolism and may have beneficial effects on cardiac and nerve function," wrote F. Guideri and colleagues at University of Siena, "we investigated the effects of long-term treatment with acetyl-L-carnitine on heart rate variability and...

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