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Cardiovascular Week

Susan Hasty, Publisher

Table of Contents . . . February 27th, 2006

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Cardiovascular Week | Other Publications

Angiology - Nebivolol is novel beta-blocker with endothelium-derived NO enhancement benefit

Cardiomyocytes - Impaired coronary and myocardial flow in aortic stenosis is associated with apoptosis

Disease Associations - Mild renal insufficiency is linked to reduced coronary flow in nonobstructive CAD patients

Heart Failure - NT-proBNP testing helps evaluate dyspnea with suspected congestive heart failure

Heart Failure - Report describes unrecognized syndrome associated with congestive heart failure

Alcohol Use - Fourteen or more alcoholic drinks per week are associated with lowest CAD risk

Anesthesia - Using intrathecal morphine with remifentanil enhances post-OPCAB analgesia

Angina - U.S. FDA approves Ranexa

Angiology - Adverse CV influence of low testosterone may be mediated via vascular structure, function

Angiology - Combined iliac endovascular intervention, infra-inguinal reconstruction may reduce operative risk

Angiology - PPARgamma regulates Ang II-stimulated phosphatidylinositol 3-kinase

Angiology - Remodeling characteristics of minimally diseased coronary arteries are consistent

Angiology - Researchers provide details of new studies and findings in the area of angiology

Angiology - Rho kinase mediates endothelial tension development in microvascular leakage

Angiology - Skin cholesterol content identifies increased carotid intima-media thickness

Atherosclerosis - Chest radiotherapy does not affect outcome of myocardial internal thoracic artery grafts

Atherosclerosis - Estradiol valerate plus levonorgestrel therapy reduces plasma trans-fatty acid

Atherosclerosis - Local vascular endothelial growth factor gene transfer may not prevent arterial restenosis

Atherosclerosis - New findings in the area of atherosclerosis detailed

Atherosclerosis - Reports describe recent advances in atherosclerosis research

Atherosclerosis - Threshold value may exist in atherosclerosis progression

Atherosclerosis Vaccines - Pathogen-accelerated atherosclerosis can be prevented by immunization

Biomedical Engineering - Injectable nanofibers allow controlled protein delivery to myocardium

Biomedical Engineering - Site-directed immobilization of antibody fragments allows detection of C-reactive protein

Cancer Therapy - Cancer organization updates to several clinical practice guidelines

Cardiac Arrhythmia - Cardiac Cryoablation System not approvable, U.S. FDA determines

Cardiac Regeneration - Evidence supports use of mesenchymal stem cells for cardiac regeneration

Cardiology - 16-slice MSCT suitable for monitoring of large coronary stents

Cardiology - A woman's waist measurement is a predictor of heart disease

Cardiology - Apex-to-base relaxation gradients may facilitate restoration of LV cavity in diastole

Cardiology - Avoiding microbubbles in RF ablation energy delivery yields best results

Cardiology - Beta-blockers remain a cornerstone of cardiovascular therapy

Cardiology - Coronary distal emboli particle size affects myocardial perfusion

Cardiology - Increase in QTc interval duration predicts mortality in heart transplant patients

Cardiology - Long Distance Corridor Walk provides valid estimate of peak VO2 in older adults

Cardiology - Most short-term heart rate variability measures are highly stable over time

Cardiology - New findings in the area of cardiology detailed

Cardiology - Novel steerable lead placement catheter enables direct His-bundle pacing

Cardiology - Reports add new data to cardiology research

Cardiology - Reports describe recent advances in cardiology research

Cardiology - Researchers provide details of new studies and findings in the area of cardiology

Cardiology - Researchers report details of new studies and findings in the area of cardiology

Cardiology - Researchers studied natural history of valvular regurgitation in anorexigen-treated subjects

Cardiology - Sirolimus-eluting stent may reduce re-blockage in complex coronary lesions, study shows

Cardiology - Studies add new findings to cardiology body of knowledge

Cardiology - Study compared mapping criteria for postinfarction ventricular tachycardia

Cardiology - Study found no differences in RF ablation between normal vs. scarred myocardium

Cardiology - T-wave ratio in 24-h ECG is an indicator of symptom history in long-QT syndrome

Cardiology - The role of GH in cardiovascular risk in aging and obese is reviewed

Cardiology - Thirty patients receive non-surgical replacement for diseased aortic heart valve

Cardiomyocytes - Beta-myosin heavy chain myocytes are more resistant to power output changes during ischemia

Cardiomyocytes - Human atrial cardiomyocytes express an outwardly rectifying chloride channel

Cardiovascular Disease - Cardiovascular benefits of nebivolol persist long after therapy withdrawal in rat model

Cardiovascular Disease - Caval division for partial anomalous pulmonary venous connection appears safe

Cardiovascular Disease - Clopidogrel with early interventional strategy is associated with low CV event rates

Cardiovascular Disease - Differences in disease presentation may require gender-specific therapy for heart disease

Cardiovascular Disease - Family CHD history is excluded from risk calculation in electronic health records

Cardiovascular Disease - Management of coronary heart disease is focus of review

Cardiovascular Disease - Nearly half of people who need cholesterol treatment don't get it

Cardiovascular Disease - Pharma company introduces heart disease campaign to help women with physician conversations

Cardiovascular Disease - Review focuses on diagnosis and screening of coronary artery disease

Cardiovascular Disease - Routine auscultation is valuable for pre-op detection of valvular heart disease

Cardiovascular Disease - Significant narrowings are present in septal branches in hypertrophic cardiomyopathy

Cardiovascular Disease - Single bolus dalteparin may be alternative to unfractionated heparin during PCI

Cardiovascular Disease - Socio-economically patterned access to medical care may be factor in SES and CVD relation

Cardiovascular Disease - Strategic sampling of NT-pro BNP concentration could inform management of ACS patients

Cardiovascular Disease - Study finds immune cells that protect against heart disease

Cardiovascular Disease - Thrombus formation, large plaque burden increase risk for transient no-reflow during PCI

Cardiovascular Disease - Urban U.S. black women underestimate heart disease risk

Cardiovascular Disease - Vascular or mixed hemodynamic profile measured during lab stress may be CVD risk marker

Cardiovascular Research - Engineered heart tissue offers insights into irregular heartbeats

Cardiovascular Research - Heart-type fatty acid-binding protein is an early marker of myocardial injury

Cardiovascular Therapy - Phase III study examines ability of drug to slow atherosclerosis

Chronic Obstructive Pulmonary Disease - Emotional burden of COPD may make patients reluctant to seek treatment, survey shows

Clinical Trials - Phase 2 program of antisense drug in patients with familial high cholesterol initiated

Clinical Trials - Report announces the MICHELANGELO OASIS-5 trial evaluating fondaparinux

Clinical Trials - WAVE trial to determine if oral anticoagulation improves on antiplatelet therapy alone

Collaborations - Commercialization deal signed for atherosclerosis treatment

Complementary & Alternative Medicine - Perioperative magnesium doesn't prevent post-OPCAB atrial fibrillation

Coronary Artery Bypass - Researchers report details of new studies and findings in the area of coronary artery bypass

Coronary Heart Disease - Diabetes increases risk of heart disease, even in women without prior cardiovascular events

Coronary Stenting - Heparin coronary stent coating may not reduce thrombosis risk

Critical Care Medicine - Chest re-exploration in ICU can be alternative to returning to operating theater

Critical Care Medicine - Noninvasive ventilation improves outcome of acute cardiogenic pulmonary edema

Diabetes Drugs - Approval and availability of Avandaryl (rosiglitazone maleate and glimepiride) announced

Diabetes Pathogenesis - PI3K signaling pathway inhibition leads to lower insulin-stimulated adiponectin secretion

Diabetes Pathogenesis - Researchers' data advance diabetes pathogenesis research

Diabetes Research - Model for myocardial infarction and heart failure in db/db diabetic mouse is developed

Diabetes Research - Nitric oxide scavenger AMD6221 augments cardiac response to noradrenaline in rat model

Diabetes Therapy - Researchers provide details of new studies and findings in the area of diabetes therapy

Diabetes Therapy - Rosiglitazone improves exercise capacity in individuals with type 2 diabetes

Diagnostics - Analysis of regional wall motion abnormalities shows interobserver variability

Diagnostics - ECG and natriuretic peptide tests have comparable accuracy in LVSD diagnosis

Diagnostics - Gastroesophageal reflux disease is most common esophageal disease associated with noncardiac chest pain

Diagnostics - Mitral leaflet separation index facilitates mitral stenosis assessment

Diagnostics - Parameters improve LV hypertrophy detection in resistant hypertension

Diagnostics - Recent studies add new data to diagnostics research

Diagnostics - Researchers publish new studies and findings in the area of diagnostics

Diagnostics - Vector magnetometers improve standardization of fetal MCG waveforms

Diet & Nutrition - Fortified chocolate is good for the heart, but there is a catch

Diet & Nutrition - Nutritional therapy is a component of treatment of CVD in dyslipidemic patients

Diet & Nutrition - Palm oil replacement with polyunsaturated vegetable oil may lower myocardial infarction risk

Diet & Nutrition - Soy's cardiovascular benefits may be overestimated

Disease Associations - High blood pressure, kidney disease increase heart disease risk in older Americans

Disease Associations - Increased pulse wave velocity, diastolic BP are demonstrated in subclinical hypothyroidism

Disease Associations - Patients with vasculogenic erectile dysfunction should be evaluated for silent CAD

Disease Associations - Population-based study finds no link between prior myocardial infarction and dementia

Drug Development - APEX-AMI pexelizumab trial to complete enrollment in March

Drug Development - Pharmaceutical firm focused on diseases of aging and diabetes provides clinical pipeline update

Drug Resistance - Routine screening for antiplatelet drug resistance should not yet be standard practice

Echocardiography - Real-time transthoracic 3-dimensional ECG is feasible for volumetric analysis of abnormal LV

Echocardiography - Report presents an ECG LV wall area index for myocardial injury detection

Echocardiography - Report presents an ECG study of diastolic function in young patients with beta-thalassemia major

Electrocardiography - Electrocardiogram is a valuable tool in the primary care office

Electrocardiography - Electrocardiographic manifestations of noncoronary heart disease are focus of review

Epidemiology - Obesity epidemic will likely lead to increase in metabolic syndrome prevalence

Fetal Medicine - Pro-inflammatory cytokines inhibit placental 11beta-hydroxysteroid dehydrogenase type 2 activity

Finance - Adult-stem-cell company receives $11.0 million milestone payment from Olympus-Cytori

Finance - Cardiac device maker reports 10% increase in revenue

Finance - Cardiovascular products company reports record Q4 revenue, 2005 revenues up 17% to $202 million

Finance - Cardiovascular technologies company reports Q4 2005 net revenue of $38.6 million

Finance - Innovent invests in Quantum Intech

Finance - Maker of cardiology instruments announces closing of common stock offering

Fitness & Wellness - Estrogen replacement therapy was not found to enhance cardiopulmonary response to exercise

Fitness & Wellness - Reports add new data to fitness & wellness research

Genetics & Genomics - Findings advance knowledge in genetics & genomics research

Genetics & Genomics - Review examines sarcomeric proteins and familial hypertrophic cardiomyopathy

HIV/AIDS HAART - Ritonavir impairs lipoprotein lipase-mediated lipolysis

HIV/AIDS Tobacco Use - Tobacco smoking increases mortality and decreases quality of life in HIV/AIDS

Health Promotion - Recommendations for community interventions for cardiovascular disease are presented

Healthcare Costs - Health care costs are similar for heart failure with normal vs. reduced ejection fraction

Healthcare Costs - International differences persist in the cost of acute myocardial infarction

Heart Failure - CHF patients with reduced ejection fraction had higher mortality rates

Heart Failure - Forty U.S. centers enrolling heart failure patients in new pacing device safety study

Heart Failure - NT-proBNP testing is valuable for diagnosis, short-term prognosis in dyspneic patients

Heart Failure - Prognostic value of cardiopulmonary exercise testing in heart failure is unaffected by mode of exercise

Heart Failure - Research reports a validated clinical, biochemical score for diagnosis of acute heart failure

Heart Failure - Review examines drugs for left ventricular remodeling in heart failure

Heart Failure - Studies add new findings to heart failure body of knowledge

Heart Failure - Systole is significantly prolonged, diastole correspondingly shortened in children with HF

Heart Failure - Unique patient profile characterizes HF with preserved systolic function

Heart Failure - Urodilatin may be new therapeutic agent in treatment of decompensated chronic heart failure

Heart Failure - Use of spironolactone in severe CHF patients does not preclude need for beta blockers

Hematology - Dipyridamole decreases protease-activated receptor and annexin-v binding on platelets

Hypertension - Active lifestyle may prevent hypertension in normotensive women

Hypertension - Beta-blockers worsen pulmonary dynamics in portopulmonary hypertension patients

Hypertension - Hypertension-associated nucleotide polymorphism did not diminish treatment efficacy with irbesartan

Hypertension - Review examines role of the new beta-blockers in treating cardiovascular disease

Hypertension - Selective ANGII receptor antagonism raises insulin sensitivity and glucose transport rat model

Hypertension - White coat effect is strongly positive in most hypertensive patients

Imaging - Contrast ultrasound perfusion imaging is a novel diagnostic method in peripheral arterial disease

Imaging - Data advance knowledge in imaging research

Imaging - High-resolution real-time spiral MRI shows promise for guiding coronary interventions

Imaging - Imaging company introduces fetal monitors with new functionality and documentation

Imaging - Imaging company reports ISO certification

Imaging - Imaging techniques visualize hepatocellular carcinoma in chronic liver disease

Imaging - Myocardial perfusion imaging with ATP is as effective as dipyridamole for diagnosis of CAD

Imaging - New findings in imaging described

Imaging - New findings in the area of imaging described

Ischemia - A protein kinase modulates GluR6 Ser phosphorylation during cerebral ischemia

Ischemia - Findings in ischemia provide new insights

Ischemia - Intraluminal hyperoxygenated solution minimizes mitochondrial structural and functional changes

Kidney Disease - Continuous hemodynamic monitoring may improve volume management for dialysis patients

Kidney Disease - Endothelial function improves for dialysis patients after renal transplantation

Kidney Disease - Renal insufficiency remains an independent predictor of adverse outcome after PCI

Leukemia - Research add new data to leukemia body of knowledge

Lung Cancer - Extended resection of T4 lung cancer with invasion of the aorta justified

Market Analysis - Generics erosion will lead to slow market growth for chronic heart failure treatment

Medical Devices - Angio-Seal vascular closure device suitable for use in neuroradiological interventions

Medical Devices - Fifth VentrAssist implanted in U.S. feasibility trial

Medical Devices - First patient enrolled in study of implantable cardioverter defibrillators and home monitoring

Medical Devices - New hypotube launched for catheter manufacturers

Medical Devices - Safety information released about older model pacemakers

Medical Devices - Study of cardiovascular EKG/ECG monitor completed at Duke University

Medical Devices - U.S. FDA clears two new Troponin-I assays

Mental Health - Depression is not linked to pro-inflammatory cytokine production in CAD patients

Mental Health - Onset, aggravation of serious illness is suggested as new criterion for depression severity

Mergers & Acquisitions - Acquisition of 25% of BioPad completed, human testing of noninvasive fetal monitor begun

Metabolic Syndrome - Older adults may reduce risk of metabolic syndrome by eating more whole grains

Migraine Headaches - U.S. FDA approves new formulation of Imitrex injection

Myocardial Infarction - Granulocyte colony-stimulating factor augments cellular cardiomyoplasty in the injured heart

Myocardial Infarction - New findings in myocardial infarction described

Myocardial Infarction - New findings in the area of myocardial infarction described

Myocardial Infarction - One in 14 Irish men having a heart attack drives self to hospital

Myocardial Infarction - ST deviation, troponin elevation are predictors of outcome in unstable angina

Neonatal Cardiology - Early surgical closure of ductus arteriosus allows earlier feeding, improved body growth

Neuroscience - Angiotensin II type 1 receptor blockade supports cerebral cortex angiogenesis

Obesity - French may be headed for American levels of obesity, diabetes, and heart disease

Obesity Complications - AII-induced Na+, K+-ATPase activation in proximal tubules may lead to hypertension

Obesity Complications - Cardiac contractile dysfunction in ventricular myocytes found in mouse model

Obesity Pathogenesis - -308A TNF-alpha gene variant is linked to 23% risk of developing obesity and related diseases

Obesity Pathogenesis - IMT in childhood obesity indicates higher cardiovascular disease and diabetes risk

Obesity Pathogenesis - Obesity is emerging epidemic in developing countries

Obesity Pathogenesis - Reports describe recent advances in obesity pathogenesis research

Obstetrics - High levels of HtrA1 protein may be biomarker of preeclampsia

Obstetrics - Medical equipment company licenses placental protein 13, a biomarker for preeclampsia

Obstetrics - New study data support periodontitis link to increased risk of preeclampsia

Obstetrics - Omega-3 fatty acids taken by pregnant women have positive impact on child's development

Obstetrics - Smoking during pregnancy increases risk of overweight offspring

Pediatric Cardiology - Catheter ablation in children and adolescents is focus of review

Pediatric Cardiology - Research in pediatric cardiology provides new insights

Pediatric Cardiology - Study determines predictors of survival in congenital diaphragmatic hernia

Peripheral Arterial Disease - Clinical trial underway to test stem cell therapy for peripheral arterial disease

Peripheral Arterial Disease - U.S. FDA fast track status granted for rifalazil in peripheral arterial disease

Personnel - Biopharma company elects Jean-Pierre Millon as chairman of the board

Personnel - Company focused on blood viscosity appoints Dr. Ralph E. Holsworth, Jr. to management team

Pulmonary Embolism - U.S. FDA awards conditional IDE for SafeFlo Retrievable Vena Cava Filter

Pulmonary Hypertension - Drugmaker in-licenses pulmonary hypertension compound for development

Sleep Apnea - Acetazolamide improves central sleep apnea in heart failure

Sleep Apnea - Researchers' findings advance sleep apnea research

Sociology Research - Bounded awareness, cognitive blinders can prevent risk recognition in decision making

Statins - Findings in statins provide new insights

Statins - New findings in the area of statins described

Statins - Questions regarding benefits of statin therapy are focus of review

Statistics - Multiple logistic regression is being applied to multiple inverse sampling design

Stroke - Gender differences in attitude may influence decision-making for stroke patients

Stroke - Half of patients with atherothrombotic cerebral infarction have other atherothrombotic sites

Surgical Technology - Novel balloon-type device may facilitate atrial fibrillation surgery

Surgical Technology - PTA with selective stent placement in iliac artery had better symptomatic success

Transplant Medicine - Studies describe new findings in transplant medicine research

Type 2 Diabetes - Increased NT-proBNP plasma levels were found in diabetics with vascular complications

Type 2 Diabetes - Rosiglitazone plus sulfonylurea drugs improved insulin resistance and beta-cell function

Ulcerative Colitis - European Medicines Agency CHMP recommends approval of Remicade for ulcerative colitis

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