Atherosclerosis

Polymorphonuclear leukocyte priming is potential risk factor for atherosclerosis development

Published in Cardiovascular Week, May 29th, 2006

Recent data support a pathogenic link between peripheral polymorphonuclear leukocyte priming and endothelial dysfunction, suggesting that PMNL priming is a potential new nontraditional risk factor for the development of atherosclerosis.

According to recent research from Israel, "Peripheral polymorphonuclear leukocytes (PMNL) in hemodialysis (HD) patients are primed, continually releasing and exposing the vascular endothelium to soluble factors such as reactive oxygen species and inflammatory mediators.

"To mimic the close proximity between PMNL and the endothelial monolayer and to monitor and characterize the influence of soluble mediators released...

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Source: Cardiovascular Week (2006-05-29)

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