Heart Failure
Heart failure occurs when hearts with cardiac hypertrophy are deprived of VEGF
Published in Cardiovascular Week, June 12th, 2006
"Cardiac hypertrophy is associated with upregulation of VEGF in the myocardium. Here, we evaluated the effects of a decoy VEGF receptor on heart morphology and function to a murine model of pressure overload hypertrophy," scientists in the United States report.
"Mice were administered adenoviral vector encoding a decoy VEGF receptor (Ad-Flk), and their hearts were subjected to pressure overload by transverse aortic constriction (TAC). Treatment with Ad-Flk led to a net reduction in capillary density in hearts subjected to TAC. Ad-Flk...
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Source: Cardiovascular Week (2006-06-12)
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