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Cardiology & Neurocognitive Decline

CPB-associated neurocognitive injury correlates with transcerebral platelet activation

Published in Cardiovascular Week, June 12th, 2006

Transient intracerebral platelet activation is correlated with postcardiopulmonary bypass (CPB)-associated neurocognitive injury.

"Neurocognitive decline after cardiac surgery requiring CPB may be caused in part by highly prothrombotic atheroemboli to the brain; the source of these emboli is likely the ascending aorta and aortic arch. We examined transcerebral platelet activation gradients using simultaneous measurements in arterial and jugular venous blood and then compared gradients with post-CPB-associated neurocognitive injury," investigators in the United States report.

"Eighty-one patients undergoing elective coronary artery bypass graft...

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