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Cardiomyogenesis

Parietal endoderm secreted S100A4 promotes early cardiomyogenesis in embryoid bodies

Published in Cardiovascular Week, June 12th, 2006

Parietal endoderm secreted S100A4 promotes early cardiomyogenesis in embryoid bodies.

According to a study from Austria, "Cardiomyogenesis is influenced by factors secreted by anterior-lateral and extra-embryonic endoderm. Differentiation of embryonic stem cells in embryoid bodies allows to study the influence of growth factors on cardiomyogenesis. By these means SPARC was identified as a new factor enhancing cardiomyogenesis."

"Here we report a similar and new function for S100A4, a calcium-binding protein of the EF-hand type. S100A4 is secreted by parietal endoderm and promotes early differentiation and proliferation of cardiomyocytes.

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