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Adverse Drug Reaction

Adverse effects of PI-containing regimens may put HIV-infected children at risk for CVD

Published in Cardiovascular Week, June 12th, 2006

HIV-1 infected children on protease inhibitor-containing HAART have a higher risk of developing hypercholesterolemia, hypertriglyceridemia and cardiovascular disease.

"Protease inhibitor (PI)-containing regimens have led to improved survival among HIV-infected children. However, adverse effects, including dyslipidemia, may put children at risk for cardiovascular disease," investigators in the United States report.

According to R.J. Carter and colleagues at Columbia University, College Physicians & Surgeons in New York, "Serum cholesterol and triglyceride levels were recorded on perinatally HIV-infected children participating in the PACTS-HOPE cohort...

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