Cardiovascular Week

Angiology - Bile acids induce adhesion molecule expression via ROS, NF-kappa B, and p38 activation

Cardiovascular Disease - Alcoholic cardiomyopathy is prevented by angiotensin II type 1 receptor blockade

Cardiovascular Disease - Model of classic risk factors plus Nt-proBNP was best predictor of recurrent cardiovascular events

Ischemia - Perinatal hypoxia may lead to sex-dependent changes in cardiac tolerance to ischemia in later life

Adverse Drug Reaction - Adverse responses to rosiglitazone in type 2 diabetes model can be predicted by genetics

Angiology - C-reactive protein promotes platelet adhesion to endothelial cells, a pathway in atherothrombosis

Angiology - Endovascular stent-grafting of descending aortic aneurysms performed in high-risk patients

Angiology - Femoropopliteal aneurysm endovascular repairs are assessed

Angiology - Mechanisms of nebivolol-induced vasodilation have been identified

Angiology - Multislice spiral CT angiography role in endovascular-treated patients is determined

Angiology - Plethysmography and rheography are not stand-alone tests for deep vein thrombosis

Angiology - Rat cerebral arteries show evidence for two-pore domain potassium channels

Angiology - Thromboplastin sensitivity to clotting factors can be modulated

Angiology - Transfemoral port-catheter system withdrawal complications are assessed

Angiology - Tubular graft in the descending thoracic aorta may improve left ventricular performance

Arthritis Therapy - Osteoarthritis pain treatment strategies are reviewed for safety in African Americans

Atherosclerosis - Atherosclerosis involves transcription activator-mediated muscle cell proliferation

Atherosclerosis - Atherosclerotic model is developed using transgenic mice expressing MPO-463G/A alleles

Atherosclerosis - Cardiovascular disease risk is linked to soluble CD40 ligand, interleukin-6, and oxidized LDL

Atherosclerosis - Coronary artery atherosclerosis is linked to reduced extracellular superoxide dismutase

Atherosclerosis - Endothelial dysfunction, plaque echogenicity are signaled by tissue-plasminogen activator

Atherosclerosis - Very low-density lipoprotein hydrolysis plays a key role in mediating proinflammatory effects

Business & Finance - Cardiogenesis announces results for second quarter and first half of 2006

Business & Finance - Diversified business portfolio helps Medtronic report strong first quarter earnings per share

Business & Finance - Kensey Nash Q4 and FY 2006 results at high end of estimates

Business Update - Advanced Cardiac Life Sciences develops CardioVance, website for women's heart disease

Business Update - CardioVascular BioTherapeutics co-founder presents seminar on potential new heart disease treatment

Business Update - Corazonas Foods spins out from Brand New Brands

Business Update - SyntheMed receives CE Mark approval for bioabsorbable adhesion barrier for cardiac surgery

Business Update - Thoratec and Levitronix announce U.S. co-distribution agreement for Levitronix CentriMag System

Business Update - U.S. FDA expands indication for automated ablation system to treat ventricular tachycardia

Carcinogenesis - Soluble nickel compounds are carcinogenic

Cardiology - Anesthetic preconditioning occurs when protein kinase upregulates proangiogenic cytokines

Cardiology - Atrial conduction slowing in dilated atria is improved by rotigaptide

Cardiology - Cardiac resynchronization therapy atrial fibrillation burden decreases after implantation

Cardiology - Cardiovascular nurses need to develop a heightened awareness of future and comorbid risks

Cardiology - Functional tricuspid regurgitation severity is linked to eccentric right ventricular dilation

Cardiology - Idiopathic ventricular fibrillation prognosis may be determined using scintigraphy

Cardiology - Implantable cardioverter defibrillator-linked pericardial tamponade management is studied

Cardiology - Marfan syndrome-associated minor cardiovascular criteria are determined

Cardiology - Myofibril organization involves muscle-specific protein

Cardiology - Pacing from the left ventricular apex improves left ventricular function

Cardiology - Percutaneous mitral valvuloplasty improves left atrial mechanical functions

Cardiology - Proepicardial cell differentiation receives help from interactive proteins

Cardiology - Quantitative QRS duration predicts cardiovascular mortality

Cardiology - R and L ventricular stroke volume variation was increased by positive end-expiratory pressure

Cardiology - Rhythm control after percutaneous mitral balloon valvotomy is preferred initial therapy

Cardiology - Type II mitral valve dysfunction is best evaluated using 3-dimensional image reconstruction

Cardiology - Ventricular assist device implantation using a right thoracotomy is described

Cardiomyocytes - Cardiomyocyte contractility, Ca transients are enhanced by endogenous inhibitor of Na/Ca exchanger

Cardiopulmonary Bypass - Fluid gain is reduced during cardiopulmonary bypass by infusing hyperosmolar/hyperoncotic solution

Cardiopulmonary Resuscitation - Thrombolytic agents improve outcome for patients treated with cardiopulmonary resuscitation

Cardiothoracic Surgery - Pectoralis major flap operation for deep sternal wound infection has good long-term outcome

Cardiovascular Disease - Acute coronary event incidence is increased by high inflammation-sensitive proteins

Cardiovascular Disease - Altered lipid metabolism in women with polycystic ovary syndrome may indicate heart disease risk

Cardiovascular Disease - Angiogenesis-dependent heart diseases are candidates for redox targeting

Cardiovascular Disease - Arteriovenous communications in peripheral femoral arterial system in diabetes is uncommon

Cardiovascular Disease - Cardiovascular disease events are confirmed in recent medical records in diabetes

Cardiovascular Disease - Cardiovascular risk is less strongly marked by augmentation index than other arterial measures

Cardiovascular Disease - Colorectal neoplasia and coronary artery disease incidence show strong correlation

Cardiovascular Disease - Factor XI contributes to thrombus propagation on injured neointima of iliac artery

Cardiovascular Disease - Fractional flow reserve helps identify intermediate or equivocal left main coronary artery disease

Cardiovascular Disease - Imaging of Turner syndrome patients is warranted at first consultation, then every two years

Cardiovascular Disease - Iron deficiency in cyanotic adults is common, but does not alter viscosity

Cardiovascular Disease - Nonsignificant left main coronary artery disease mortality risk in PCI patients is described

Cardiovascular Disease - Perivascular adipose tissue promotes vasoconstriction through superoxide anion production

Cardiovascular Disease - PPAR gamma agonist effects on cardiovascular function in obese nondiabetics are reviewed

Cardiovascular Disease - Socioeconomic inequalities in coronary event incidence were tied most to job status

Cardiovascular Disease - Sudden cardiac death risk is linked to higher trans-18:2 and lower trans-18:1 fatty acid levels

Cardiovascular Disease - Use of C-reactive protein in predicting cardiovascular disease risk is focus of review

Cardiovascular Research - Abdominal aortic hemodynamics in adults at rest/during lower limb exercise were quantified

Cardiovascular Research - Artificial cardiac valve flow is characterized using numerical dye washout technique

Cardiovascular Research - Cardiovascular disease prevention may include magnesium supplementation as adjuvant therapy

Cardiovascular Research - Continuous cardiac output monitoring technique is developed and tested

Cardiovascular Research - Coronary venule wall thickness is increased prior to retroperfusion by novel strategy

Cardiovascular Research - Gene expression, cardiac injury response to doxorubicin are modulated by disruption of COX-2

Cardiovascular Research - Individual physician judgment is key to choosing the most beneficial therapy

Cardiovascular Research - Isosorbide dinitrate- or sildenafil-induced BP changes in dogs were unaltered by ranolazine

Cardiovascular Research - Merck's early analyses show thrombotic cardiovascular events similar in NSAID, COX-2 drugs

Cardiovascular Research - Mixed flow blood pump prototype is designed and tested

Cardiovascular Research - Mouse cardiac muscle dynamics are affected by changes in end-to-end interactions of tropomyosin

Cardiovascular Research - Physical activity after a high-fat meal reverses the arterial dysfunction caused by fatty foods

Cardiovascular Research - Pulmonary embolism diagnosis is possible combining clinical probability and capnography

Cardiovascular Research - Specialists suggest ways to lower blood pressure

Cardiovascular Research - Type A personality is not linked to heart disease

Cellular Cardiology - Myocardial K_ATP channels play key role in protection from lethal arrhythmias

Cellular Cardiology - Uridine and uridine-5'-monophosphate are cardioprotective

Clinical Trials - Cardiovascular risk factors are improved by Mediterranean diets supplemented with olive oil or nuts

Clinical Trials - NEDO biventricular assist device development program is reviewed

Clinical Trials - Novel antiatherosclerotic therapies will be assessed by intravascular ultrasound in ACTIVATE study

Clinical Trials - Paclitaxel-eluting stent cost effectiveness is described for patients undergoing PCI

Clinical Trials - Sirolimus-eluting stents at 2 years post-implantation demonstrate sustained efficacy, safety

Critical Care Medicine - CKD patients demonstrate renoprotection with preoperative intravenous hydration

Critical Care Medicine - Noninvasive ventilation improves preoxygenation before intubation of hypoxic patients

Depression - Antidepressants may have anti-inflammatory effects and prevent atherosclerosis development

Diabetes Complications - Adrenal gland induces plasminogen activator inhibitor-1 expression in diabetic model

Diabetes Complications - Vascular effects of thiazolidinediones in type 2 diabetes patients are reviewed

Diabetes Control - Improved glycemic control reduces macrovascular event incidence both types of diabetes

Diabetes Pathogenesis - Diabetes-related atrial fibrillation is associated with a remodeling of atrium

Diabetes Pathogenesis - Diabetes-related oxidative stress and impaired HSP60 expression improved by lipoic acid

Diabetes Pathogenesis - High intestinal microsomal triglyceride transfer protein expression seen in diabetics

Diabetes Pathogenesis - Peroxisome proliferator activated receptors play role in macrovascular disease protection

Diabetes Pathogenesis - Reactive oxygen species play a key role in diabetes onset and vascular dysfunction development

Diabetes Pathogenesis - Reduction in ABCG1 in type 2 diabetic mice increases macrophage foam cell formation

Diabetes Therapy - Diabetes patients benefit from global heating in response to contrast baths

Diabetes Therapy - Pioglitazone improves glycemic control and atherosclerosis risk factors in type 2 diabetes

Diabetes Therapy - Sirolimus- and paclitaxel-eluting stents have similar efficacy and safety in diabetes mellitus

Diagnostics - Exercise echocardiography has incremental value for coronary artery disease risk stratification

Diagnostics - Mapping technique differentiates activation and motion timing abnormalities in ischemic hearts

Dialysis - In hemodialysis, patients fat mass plays protective role against mortality

Diet & Nutrition - Antioxidant, hypolipidemic, and anti-inflammatory effects are exerted by red grape juice

Diet & Nutrition - Cardiovascular disease outcomes benefit from n-3 fatty acids from fish or fish oil supplements

Diet & Nutrition - Chronic kidney disease and cardiovascular disease can be treated by dietary intervention

Diet & Nutrition - Fish oils produce anti-inflammatory effects and improve body weight in severe heart failure

Diet & Nutrition - High-carbohydrate, low-glycemic index diet optimized cardiovascular risk reduction

Diet & Nutrition - High-fat feeding reduces endothelium-dependent vasodilation in rats

Diet & Nutrition - Lower severity of coronary heart disease may be associated with Mediterranean-type dietary habits

Drug Development - Cytokinetics announces initiation of Phase I clinical trial for oral administration of CK-1827452

Drug Development - Laureate Pharma to produce Lpath's Sphingomab for phase I clinical trials

Drug Development - Neuren announces favorable Phase 2a pharmacokinetic and safety data for Glypromate

Drug Safety - Diuretics may not increase gout risk

Drug Safety - The safety of heparins in end-stage renal disease is considered in review

Drug Toxicity - Cardiomyocyte toxicity in adriamycin-exposed patients is inhibited by calceolarioside

Emergency Medicine - Resuscitation termination rule for out-of-hospital cardiac arrest is developed

Endocrinology - Deferoxamine and deferiprone together improve liver iron deposition and glucose intolerance

Endocrinology - Hyperinsulinemia lowered AT1a-to-AT2 ratio and raised MEK-ERK1/2 and S6K1 pathway activity

Environmental Health - Hospitalizations for cardiovascular disease in elderly are linked to air pollution

Epidemic Dropsy - Safety levels of argemone oil through dietary exposure determined

Epidemiology - Identifying causes of cardiac death is process of limited reliability and accuracy

Finance - FibroGen awarded grant from NHLBI to develop HIF-PH inhibitors to treat sickle cell disease

Finance - Inverness Medical Innovations agrees to sell 5,000,000 shares of common stock

Fitness & Wellness - Cutaneous blood flowmotion is greater in healthy physically trained subjects

Fitness & Wellness - L-arginine supplements enhance endurance exercise tolerance in heart failure patients

Genetics & Genomics - Cardiac gene regulation involves novel zinc finger protein zipzap/p200

Genetics & Genomics - Gene expression analysis of cardiovascular diseases is focus of review

Genetics & Genomics - Novel molecular mechanism for arrhythmogenic right ventricular cardiomyopathy has been identified

Healthcare Access - Cardiac surgeon referral patterns for white and black patients are studied

Healthcare Costs - Body mass is linked to increased medical claim costs in diabetes and heart disease

Heart Failure - Aurora St. Luke's cardiac team implants artificial heart

Heart Failure - Cardiac origin of pleural effusions is marked by NT-proBNP with high diagnostic accuracy

Heart Failure - Chronic heart failure is marked by reduced peripheral muscle mass, abnormal reflex physiology

Heart Failure - Chronic left ventricular filling pressures in stable heart failure patients are related to BNP levels

Heart Failure - Circulating urocortin 1 sources were identified in heart failure model

Heart Failure - Drug treatment of heart failure in the very old needs improvement

Heart Failure - Improved ventricular contractility with levosimendan is enhanced by long-term amiodarone treatment

Heart Failure - Lower incident congestive heart failure risk is associated with moderate alcohol use in older adults

Heart Failure - Mitral regurgitation during exercise in chronic heart failure patients was reduced by CRT

Heart Failure - Systolic heart failure community screening is augmented by combined markers

Heart Transplant - BK viral reactivation in cardiac transplant patients is evidence for double-hit hypothesis

Heart Transplant - Growth failure in children after cardiac transplant can be treated effectively with growth hormone

Heart Transplant - Heart transplant patients have a lower incidence of atrial fibrillation

Hematology - Flow cytometry-sorted non-viable endotoxin-treated human monocytes are strongly procoagulant

Hematology - Thrombotic microangiopathy factors for resistance to plasma exchange are determined

Hepatitis C Virus - Co-infection involving hepatitis C does not influence viral clearance

Hyperinsulinemia - Insulin-induced modifications in fatty acid oxidative metabolism alters [¹⁸F]FTHA in rats

Hypertension - Left ventricular function is improved by cilnidipine as evaluated by tissue Doppler Tei index

Hypertension - LV diastolic function in hypertensive patients is characterized by Doppler tissue imaging

Hypertension - Risk stratification in untreated hypertensive patients is unaffected by CRP and echocardiography

Imaging - 32-channel MR system for accelerated volumetric breath-hold coronary MR angiography is described

Imaging - Aging affects systolic component of twist displacement loop by 2D speckle-tracking imaging

Imaging - Carotid artery atheroma detection by digital panoramic radiography may have diagnostic value

Imaging - Coronary artery stenosis assessment by 16-row MDCT is limited

Imaging - Enhanced washout of ¹²³I-MIBG occurs in autonomic failure, Parkinson, and dementia

Imaging - New strategy for respiration compensation is applied to 3D free-breathing cardiac MRI

Imaging - Regional LV function was assessed using pixel tracking in 2D echocardiographic images

Immunotherapy - Granulocyte macrophage colony stimulating factor is a promising therapy for autoimmune lung disease

Inflammatory Bowel Disease - Antibodies could contribute to the prothrombotic state of inflammatory bowel disease

Information Technology - Indiana Heart Associates selects Allscripts for electronic health records

Ischemia - Delayed cardioprotection is induced by calreticulin through mitogen-activated protein kinases

Ischemia - Epicardial action potentials and response to ischemia-reperfusion are unchanged by brain death

Ischemia - Epoxyeicosatrienoic acid cardioprotection is mediated by cardiac K_ATP channels

Ischemia - Ischemia/reperfusion injury is weakly protected against by overexpressing catalase

Ischemia - PARP-1 hyperactivation is linked to mitochondrial respiratory chain complex I dysfunction

Ischemia - Post ischemia-reperfusion myocardial infarct size reduced by transcription targeting

Ischemia - Transient forebrain ischemia is associated with tau factor hyperphosphorylation

Ischemic Stroke - Cardiac glycosides provide neuroprotection against ischemic stroke

Kidney & Cardiovascular Disease - Kidney dysfunction link with heart failure is stronger in blacks than whites

Kidney Disease - Online hemodiafiltration advantages are reviewed

Legal Issues - Attorney announces $51 million verdict in Vioxx case

Liver Disease - Coronary risk factors are high in end-stage liver disease being evaluated for liver transplant

Market Analysis - Report examines risk factors for heart disease in Type 2 diabetes

Medical Devices - Dual chamber ICD performance is not adversely affected by advanced atrial detection

Medical Devices - Hemodynamic counterpulsation device is developed for long-term use

Medical Devices - Mechanical heart valve squeeze flow phenomenon squeeze likely source for potential cavitation

Medical Devices - Rotary left ventricular assist device is capable of inducing artificial pulse

Medical Devices - U.S. FDA approves timing cycle optimization device for heart failure and ICD patients

Mental Health - Depression/anger expression is associated with increased risk of Type 2 diabetes in women

Mental Health - Quality of life in angioplasty patients is improved by behavioral intervention

Mental Health - Role of hostility in cardiovascular health is mediated by sense of coherence

Mergers & Acquisitions - Oscient Pharmaceuticals acquires, commercializes cardiovascular therapy Antara (fenofibrate)

Migraine Therapy - Sumatriptan acutely increases aortic blood pressure, stiffness, and augmentation index