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Cardiovascular Disease

Factor XI contributes to thrombus propagation on injured neointima of iliac artery

Published in Cardiovascular Week, September 18th, 2006

Factor XI contributes to thrombus propagation on injured neointima of the rabbit iliac artery.

According to a study from Japan, "Thrombus formation through the activation of tissue factor (TF) and factor (F) XI is a critical event in the onset of cardiovascular disease. TF expressed in atherosclerotic plaques and circulating blood is an important determinant of thrombogenicity that contributes to fibrin-rich thrombus formation after plaque disruption. However, the contribution of FXI to thrombus formation on disrupted plaques remains unclear."

"A mouse monoclonal antibody against FXI and activated FXI (FXIa) (XI-5108) was generated by immunization...

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