Addiction Medicine

Nicotine-induced endothelial dysfunction is prevented by captopril

Published in Cardiovascular Week, October 23rd, 2006

Research from the People's Republic of China reports that captopril protects from nicotine-induced endothelial dysfunction.

"This study was designed to examine the in vivo and in vitro effects of captopril, an angiotensin-converting enzyme inhibitor, on nicotine-induced endothelial dysfunction in rats," wrote H.L. Luo and colleagues of Xian Jiaotong University.

"Endothelial dysfunction was induced by exposing isolated rat mesenteric arteries to nicotine (0.01, 0.1, or 1 mM) for 24 hr using an organ culture system, or by treating rats with nicotine (2 mg/kg/day, intraperitoneally) for 4 weeks," they explained. "The protective effects of captopril were...

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Source: Cardiovascular Week (2006-10-23)

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