Ischemia Therapy
Reports outline ischemia therapy research from Paris Descartes University, Faculty of Pharmacy
Published in Cardiovascular Week, November 6th, 2006
A report, "Anti-inflammatory effects of PJ34, a poly(ADP-ribose) polymerase inhibitor, in transient focal cerebral ischemia in mice," is newly published data in British Journal of Pharmacology. According to a study from Paris, France, "Activation of poly(ADP-ribose) polymerase (PARP) is deleterious during cerebral ischemia. We assessed the influence of PARP activation induced by cerebral ischemia on the synthesis of proinflammatory mediators including the cytokines, tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) and the adhesion molecules, E-selectin and intercellular adhesion molecule-1 (ICAM-1)."
"EXPERIMENTAL APPROACH: Ischemia was induced by...
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Source: Cardiovascular Week (2006-11-06)
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