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Angiology

Neopterin induces pro-atherothrombotic phenotype in human coronary endothelial cells

Published in Cardiovascular Week, November 6th, 2006

Neopterin induces a pro-atherothrombotic phenotype in human coronary endothelial cells.

According to recent research from Italy, "Inflammation plays a pivotal role in atherothrombosis. Recent data indicate that serum levels of neopterin, a marker of inflammation and immune modulator secreted by monocytes/macrophages, are elevated in patients with acute coronary syndromes and seem to be a prognostic marker for major cardiovascular events."

"The aim of the present study was to determine whether neopterin might affect the thrombotic and atherosclerotic characteristics of human coronary artery endothelial cells (HCAECs)," wrote P. Cirillo and colleagues...

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