Atherosclerosis

Findings in atherosclerosis reported from A. Hoang and co-researchers

Published in Cardiovascular Week, October 22nd, 2007

According to recent research published in the journal Diabetologia, "'Aims/hypothesis AGE contribute to the pathogenesis of diabetic complications, including dyslipidaemia and atherosclerosis. However, the precise mechanisms remain to be established."

"In the present study, we examined whether AGE modification of apolipoprotein A-I (apoA-I) affects its functionality, thus altering its cardioprotective profile. The ability of AGE-modified apoA-I to facilitate cholesterol and phospholipid efflux, stabilise ATP-binding cassette transporter Al (ABCA1) and inhibit expression of adhesion molecules in human macrophages and monocytes was studied. Results The ability of...

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Source: Cardiovascular Week (2007-10-22)

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