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Vascular Disease

Schering-Plough Reports Two Phase II Studies of Thrombin Receptor Antagonist (TRA) Build on Findings from Previous Phase II Study

Published in Cardiovascular Week, November 5th, 2007

Schering-Plough Corporation (NYSE:SGP) today provided an update on the clinical development program for its novel oral thrombin receptor antagonist (TRA). Results from two randomized, double-blind, placebo-controlled Phase II studies in patients with vascular disease showed that TRA does not increase the rate of major or minor bleeding in patients with acute coronary syndrome or prior ischemic stroke when added to standard antiplatelet therapy. The trials were conducted in Japan as part of the global registration program for TRA.

"These findings confirm the results of the TRA-PCI Phase II trial, which were presented at the American College of Cardiology/i2 Summit...

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