Abdominal Aortic Aneurysm

Findings from University of Melbourne advance knowledge in abdominal aortic aneurysm

Published in Cardiovascular Week, February 18th, 2008

According to recent research published in the British Journal of Pharmacology, "Oxidative stress may be involved in the development of abdominal aortic aneurysms (AAAs). Previous studies indicate that antioxidants protect against AAA formation during chronic angiotensin (Ang) II infusion in apolipoprotein E-deficient (ApoE(0)) mice."

"We here examine if these protective effects also occurred in aged ApoE(0) mice. Experimental approach: Male ApoE(0) mice (50-60 weeks) were randomly divided into 4 groups: saline, Ang II (1000 ng kg (-1) min(-1) for 4 weeks), Ang II plus antioxidants (0.1% vitamin E in food plus 0.1% vitamin C in drinking water), and Ang II plus...

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Source: Cardiovascular Week (2008-02-18)

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