Angiogenesis

New angiogenesis research from Gifu University, Medical Department described

Published in Cardiovascular Week, February 18th, 2008

"Hepatocyte growth factor (HGF) is reported to protect the heart against ischemia-reperfusion injury. However, whether in vivo adenovirus-mediated HGF gene transfer before ischemia is protective against ischemia-reperfusion and its precise mechanisms are still unknown," scientists writing in the Journal of Cardiac Failure report.

"By using a rabbit model of ischemia-reperfusion injury, we demonstrate that HGF gene transfer is cardioprotective through its multiple beneficial actions, such as angiogenesis, Bcl-2 overexpression, and decreasing hydroxyl radicals, deoxyuride-5'-triphosphate biotin nick end labeling (TUNEL)-positive myocytes, and fibrotic area. After...

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Source: Cardiovascular Week (2008-02-18)

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