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Research from University of Texas yields new findings on cardiology

Published in Cardiovascular Week, March 24th, 2008

According to a study from the United States, "Insulin resistance and metabolic syndrome are rapidly expanding public health problems. Acting through the P13K/Akt pathway, insulin and insulin-like growth factor-1 (IGF-1) inactivate FoxO transcription factors, a class of highly conserved proteins important in numerous physiological functions."

"However, even as FoxO is a downstream target of insulin, FoxO factors also control upstream signaling elements governing insulin sensitivity and glucose metabolism. Here, we report that sustained activation of either FoxO1 or FoxO3 in cardiac myocytes increases basal levels of Akt phosphorylation and kinase activity. FoxO-activated...

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