Published in Cardiovascular Week, June 16th, 2008
"Ionic currents were recorded from CHO cells transfected with KCNA5 cDNA with whole-cell patch-clamp technique. The effect of AVE 123 1 on human atrial cell action potentials was explored with a computer model. KCNA5 expression resulted in typical K+ currents that activated and inactivated voltage dependently. Ascending concentrations of AVE1231 (0.1-100 mc M) led to concentration- and...
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Source: Cardiovascular Week (2008-06-16)
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