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Atrial Fibrillation

Data on atrial fibrillation discussed by researchers at University of Frankfurt

Published in Cardiovascular Week, June 16th, 2008

"Atrial-selective drug therapy represents a novel therapeutic approach for atrial fibrillation management. The aim of the present study was to investigate the mechanism of hKv1.5 channel inhibition by the atrial-selective compound AVE 1231," scientists in Frankfurt, Germany report.

"Ionic currents were recorded from CHO cells transfected with KCNA5 cDNA with whole-cell patch-clamp technique. The effect of AVE 123 1 on human atrial cell action potentials was explored with a computer model. KCNA5 expression resulted in typical K+ currents that activated and inactivated voltage dependently. Ascending concentrations of AVE1231 (0.1-100 mc M) led to concentration- and...

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