Published in Cardiovascular Week, July 21st, 2008
"We investigated the effects of two different K-ATP channel openers and antagonists on mitochondrial respiration under two different energetic conditions. Oxygen consumption was measured for complex I (pyruvate/malate) or complex II (succinate with rotenone) substrates in mitochondria from fresh guinea pig hearts. One of two mK(ATP) channel openers, pinacidil or diazoxide, was given before adenosine diphosphate in the...
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