Metaplasia

Research on metaplasia detailed by scientists at University of Colorado

Published in Cardiovascular Week, July 21st, 2008

"The earliest response of esophageal mucosa to gastric reflux is the development of oxidative damage and inflammation. These processes contribute to the development of metaplasia known as Barrett's esophagus, as well as the progression to malignancy," researchers in the United States report.

"Secretory phospholipase A(2) is a mediator of inflammation with levels that are increased in Barrett's metaplasia and carcinoma when compared with levels in normal samples. Our goal is to determine the role of secretory phospholipase A(2) in the development of reflux-associated changes in the esophageal mucosa. Secretory phospholipase A(2)-deficient mice (C57BL/6, n = 55) and mice...

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Source: Cardiovascular Week (2008-07-21)

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