Cardiology
Research on cardiology described by scientists at Yamagata University
Published in Cardiovascular Week, July 21st, 2008
Investigators publish new data in the report 'Anoxic cell core can promote necrotic cell death in cardiomyocytes at physiological extracellular PO2.' "The physical law of diffusion imposes O2 concentration gradients from the plasma membrane to the center of the cell. The present study was undertaken to determine how such intracellular radial gradients of O2 affect the fate of isolated single cardiomyocytes," investigators in Yamagata, Japan report.
"In single rat cardiomyocytes, mitochondrial respiration was moderately elevated by an oxidative phosphorylation uncoupler to augment the intracellular O2 gradient. At physiological extracellular O2 levels (2-5%), decreases...
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Source: Cardiovascular Week (2008-07-21)
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