Cardiovascular Disease

New cardiovascular disease study findings have been published by E. Arehart and colleagues

Published in Cardiovascular Week, July 21st, 2008

"Recent increased adverse cardiovascular events observed with selective cyclooxygenase-2 inhibition led to the withdrawal of rofecoxib ( Vioxx) and valdecoxib ( Bextra), but the mechanisms underlying these atherothrombotic events remain unclear. Prostacyclin is the major end product of cyclooxygenase-2 in vascular endothelium," scientists in the United States report.

"Using a naturally occurring mutation in the prostacyclin receptor, we report for the first time that a deficiency in prostacyclin signaling through its G protein-coupled receptor contributes to atherothrombosis in human patients. We report that a prostacyclin receptor variant ( R212C) is defective in...

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Source: Cardiovascular Week (2008-07-21)

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