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American Society of Nephrology

Simple lab test for bone disease linked to risk of death in dialysis patients

Published in Cardiovascular Week, August 11th, 2008

Among patients receiving dialysis for chronic kidney disease (CKD), high levels of alkaline phosphatase—a routinely measured laboratory marker of bone disease—may signal an increased risk of death, reports a study in the November Journal of the American Society of Nephrology (JASN).

"This large epidemiologic study shows, for the first time, a consistent and robust association between a high blood level of alkaline phosphatase and cardiovascular death in thousands of dialysis patients across the United States," comments Kamyar Kalantar-Zadeh, MD, of the University of California Los Angeles, one of the study authors. "If the association between alkaline phosphatase and...

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