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Cardiomyopathy

Researchers from Charite University describe findings in cardiomyopathy

Published in Cardiovascular Week, September 22nd, 2008

" To evaluate the regulation of matrix metalloproteinase (MMP)-2 in diabetic cardiomyopathy. Left ventricle (LV) function was determined by a micro-tip catheter in streptozotocin (STZ)-induced diabetic rats, 2 or 6 weeks (w) after STZ-application," scientists writing in the journal Basic Research in Cardiology report.

"LV total collagen, collagen type I and III content were immunohistologically analyzed and quantified by digital image analysis. LV collagen type I, III and MMP-2 mRNA expression was quantified by real-time RT-PCR. LV pro- and active MMP-2 levels were analyzed by zymography; Smad 7, membrane type (MT)1-MMP and tissue inhibitor metalloproteinase...

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