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Atorvastatin

New atorvastatin findings from University of Texas published

Published in Cardiovascular Week, September 29th, 2008

" We asked whether caffeinated coffee ( CC) blunts the infarct size ( IS)-limiting effects of atorvastatin ( ATV). Adenosine receptor activation is essential for mediating the IS-limiting effects of statins," investigators in the United States report.

"Caffeine is a nonspecific adenosine receptor blocker, and thus drinking CC may block the myocardial protective effects of statins. Rat received 3-day ATV (10mg/kg/day) or water by oral gavage once daily. Drinking water was replaced by water + sugar (7.5 g/100 ml), CC with sugar, or decaffeinated coffee ( DC) with sugar. On the 4th day, rats were anesthetized and underwent 30 min of coronary artery occlusion and 4 h...

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