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Karolinska Institutet

Bad cholesterol inhibits the breakdown of peripheral fat

Published in Cardiovascular Week, December 1st, 2008

[PRESS RELEASE, 20 November 2008] The so called bad cholesterol (LDL) inhibits the breakdown of fat in cells of peripheral deposits, according to a study from the Swedish medical university Karolinska Institutet. The discovery reveals a novel function of LDL as a regulator of fat turnover besides its well-established detrimental effects in promoting atherosclerosis.

The study, which is a collaboration of two research groups at Karolinska Institutet, is published in the open-access journal PLoS ONE. It shows that LDL cholesterol slows the rate of fat breakdown (i.e. lipolysis) in adipocytes, the peripheral cells responsible for fat storage. Previously, it has been known...

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