Burnham Institute

Fruit fly research may lead to better understanding of human heart disease

Published in Cardiovascular Week, December 15th, 2008

Researchers at the Burnham Institute for Medical Research (Burnham) have shown in both fruit flies and humans that genes involved in embryonic heart development are also integral to adult heart function. The study, led by Rolf Bodmer, Ph.D., was published in Proceedings of National Academy of Sciences.

Dr. Bodmer's lab has discovered that in the fruit fly Drosophila, interactions between cardiac nmr genes (TBX20 in humans) and other transcription factors, are involved in regulating cardiac performance, rhythm and heart muscle structure. TBX20, along with other congenital heart disease genes, has been previously shown to be critical to the development of the embryonic...

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Source: Cardiovascular Week (2008-12-15)

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