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Adverse Drug Reactions

Studies from A.P. Maggioni and colleagues provide new data on adverse drug reactions

Published in Cardiovascular Week, January 26th, 2009

"Uncertainties about the cardiovascular safety of sibutramine led to the SCOUT trial that is investigating sibutramine plus weight management in high-risk, overweight/obese patients. A 6-week lead-in period during which all patients received sibutramine permitted an initial assessment of tolerability," scientists writing in the Journal of Cardiovascular Pharmacology report.

"A total of 10,742 patients received sibutramine and 3.1% of these discontinued due to an adverse event; issues affecting more than 10 patients were drug intolerance, headache, insomnia, nausea, dry mouth, and constipation-, tachycardia-, and hypertension-related events. Serious adverse...

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