Enzyme Research

Scientists at University of Sheffield target enzyme research

Published in Cardiovascular Week, February 2nd, 2009

"Inflammatory activation of monocytes is an essential part of both innate immune responses and the pathogenesis of conditions such as atherosclerosis. However, the mechanisms which modulate the response of monocytes to inflammatory stimuli are still poorly understood," scientists writing in the journal International Immunology report.

"Here, we report that tribbles-2 (trb-2) is a novel regulator of inflammatory activation of monocytes. Down-regulation of trb-2 levels potentiates LPS-induced IL-8 production via enhanced activation of the extracellular signal-regulated kinase and jun kinase mitogen-activated protein kinase (MAPK) pathways. In keeping with this, the...

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Source: Cardiovascular Week (2009-02-02)

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