Physiology

Research results from University of Erlangen update knowledge of physiology

Published in Cardiovascular Week, March 16th, 2009

"Mineralocorticoid receptor (MR) activation modulates cardiac L-type Ca2+ current (I-CaL) and transient outward K+ current (I-to). The exact circumstances of MR activation, however, remain elusive," scientists in Erlangen, Germany report.

"Here, we investigate the influence of corticosteroids on MR-mediated changes in cellular electrophysiology. In vitro incubation of adult rat ventricular myocytes with the MR agonist aldosterone (100 nM, 24 h) increased I-CaL density by 34% (n= 16; p< 0.01). This effect was abrogated by co-incubation with the MR antagonist spironolactone (10 mc M). To investigate whether an increase in serum aldosterone concentration is sufficient...

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Source: Cardiovascular Week (2009-03-16)

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