Angiogenesis

Reports from Royal Victoria Hospital add new data to research in angiogenesis

Published in Cardiovascular Week, March 23rd, 2009

"Angiopoietin-1 (Ang-1) is an important regulator of angiogenesis in endothelial cells. It promotes migration, proliferation, and differentiation of cells, although the regulating factors involved in these processes remain unclear," scientists writing in the journal Arteriosclerosis Thrombosis and Vascular Biology report.

"In this study, we evaluated the contribution of the transcription factor early growth response-1 (Egr-1) to Ang-1-induced angiogenesis in human umbilical vein endothelial cells (HUVECs). Expression of Egr-1 was evaluated with real-time PCR and immunoblotting, whereas Egr-1 DNA binding activity was monitored with electrophoretic mobility shift...

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Source: Cardiovascular Week (2009-03-23)

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