Cardiovascular Week
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JAMA and Archives Journals
Medication does not appear to reduce progression of atherosclerosis
March 30th, 2009
Compared to placebo, the drug pactimibe did not effect certain measures of atherosclerosis for patients with familial hypercholesterolemia (high cholesterol levels), but these patients did have an increased incidence of cardiovascular events such as heart attack and stroke, according to a study in the March 18 issue of JAMA. One proposed method to help prevent cardiovascular disease is to block the action of acyl coenzyme A:cholesterol acyltransferase (ACAT), an enzyme involved in cholesterol accumulation. In theory, inhibition of ACAT-1 (an isoform [different form of the same protein] of ACAT) could slow the progression of atherosclerosis (process in which plaque...
Source: Cardiovascular Week (2009-03-30)
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