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Cardiovascular Week

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Ischemia



Research reports from Northwestern University provide new insights into ischemia



July 6th, 2009

"Kapur S, Wasserstrom JA, Kelly JE, Kadish AH, Aistrup GL. Acidosis and ischemia increase cellular Ca2+ transient alternans and repolarization alternans susceptibility in the intact rat heart," researchers in the United States report.

"Am J Physiol Heart Circ Physiol 296: H1491-H1512, 2009. First published March 13, 2009; doi:10.1152/ajpheart.00539.2008.-Cardiac cellular Ca2+ transient (CaT) alternans and electrocardiographic T-wave alternans (TWA) often develop in myocardial ischemia, but the mechanisms for this relationship have not been elucidated. Acidosis is a major component of ischemia, but there is no direct evidence linking acidosis-induced cellular CaT...


Source: Cardiovascular Week (2009-07-06)

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